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Iron Overload clinical trials

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NCT ID: NCT06421636 Not yet recruiting - Clinical trials for Non-transfusion Dependent Beta-thalassemia (NTDT)

A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body

FERVENT-1
Start date: September 25, 2024
Phase: Phase 2
Study type: Interventional

This study is researching an experimental drug called REGN7999 (called "study drug"). The study is focused on patients with non-transfusion dependent beta-thalassemia. The aim of the study is to see how safe and effective the study drug is. The study is looking at several other research questions, including: - Whether the study drug lowers extra iron levels in the body - What side effects may happen from taking the study drug - How much study drug is in the blood at different times - Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

NCT ID: NCT05777733 Not yet recruiting - Thalassemia Major Clinical Trials

NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major

Start date: March 23, 2024
Phase: Phase 1
Study type: Interventional

The effect of N_acetylcystein as an antioxidant on iron overload and frequency of blood transfusion in β-thalassemia major patients at Assiut Childern Hospital University And its cosubmitted for partial fulfillment of master degree in Pediatrics

NCT ID: NCT05586932 Not yet recruiting - Clinical trials for Oxidative Stress in Patient With Haemoglobinopathy and Affect it of Endocrine System

Oxidative Stress and Iron Overload in Patient With Abnormal Haemoglobinopathy

Start date: December 1, 2022
Phase:
Study type: Observational

The effects of iron overload and oxidative stress and dyslipidemia on glucose level and thyroid function in patients with abnormal hemoglobinopathy. 2- Evaluation of MDA level as a marker of oxidative stress.

NCT ID: NCT05326503 Not yet recruiting - Thalassemia Clinical Trials

Inhibitory Effect of a Polyphenol Supplement on Dietary Iron Absorption in Adults With Thalassemia

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Genetic disorders, such as thalassemia, can lead to iron overload and severe adverse health outcomes. In iron-loading thalassemia, iron overload is due to increased iron absorption. Iron accumulates in the body organs causing widespread damage. The standard treatment is iron chelation therapy and/or periodic phlebotomy to remove iron from the body; frequency of phlebotomy or chelation therapy is dependent on how quickly body iron stores accumulate. Polyphenolic compounds are very strong inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron in the gastrointestinal tract that cannot be absorbed. The investigators have recently shown in European subjects with hereditary hemochromatosis (another iron-loading disorder) that our newly-developed natural polyphenol supplement (PPS) that is rich in polyphenols, when taken with iron-rich meals or with an iron-fortified drink, reduces iron absorption by ~40%. Decreasing non-heme iron absorption in adults with iron-loading thalassemia could potentially lead to an extension of the time period between phlebotomies or chelation therapies, and therefore an improved quality of life. Therefore, in this stable iron isotope study, the investigators will study the effect the natural PPS on oral iron absorption from an iron-rich test meal or iron-fortified drink in Thai adults with iron-loading thalassemia.

NCT ID: NCT04329377 Not yet recruiting - Clinical trials for Platelet Changes in Cases of Iron Overload

Platelet Changes in Cases of Iron Overload(IO)

Start date: April 1, 2020
Phase:
Study type: Observational

Iron demand: The average daily demand to fit the cell biological metabolism is balanced between intake and lost which about 1-2 mg.

NCT ID: NCT04329286 Not yet recruiting - Clinical trials for Platelet Changes in Cases of Iron Overload

Platelet Changes in Cases of Chronic Iron Over Load

Start date: April 1, 2020
Phase:
Study type: Observational

Iron demand: The average daily demand to fit the cell biological metabolism is balanced between intake and lost which about 1-2 mg.

NCT ID: NCT02833493 Not yet recruiting - Aplastic Anemia Clinical Trials

Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload

Start date: September 2016
Phase: N/A
Study type: Observational

The investigators aim to give an overview of Iron overload(IOL) of patients with AA and low and int-1 risk MDS and their sequelae under different chelation treatment. And the investigators also aim to evaluate the relationship of LIC and T2*/R2*.

NCT ID: NCT01511848 Not yet recruiting - Sickle Cell Disease Clinical Trials

Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload

Start date: February 2012
Phase: Phase 2/Phase 3
Study type: Interventional

Interventional Allocation: Randomized Endpoint Classification: Safety/Efficacy Study of combined chelation therapy Masking: Open Label Primary Purpose: Treatment of transfusional iron overload Primary Outcome Measures: • The primary outcome measure is to assess efficacy in lowering serum ferritin level(the change in serum ferritin compared to baseline) with combining DFP and deferasirox compared to combined DFP and DFO in conditions with severe chronic iron overload; showing an up-trend of SF over previous 12 months on single chelator. Secondary Outcome Measures: • The secondary outcome measure is to determine the number of patients who will develop adverse events in order to assess safety upon administering the drugs in combination (DFP and DFX) compared to the combination of DFO and DFP.

NCT ID: NCT01121094 Not yet recruiting - Iron Overload Clinical Trials

Fetal Parenchymatic Evaluation (Liver, Spleen) Using T2* Sequences

Start date: June 2010
Phase: N/A
Study type: Observational

The purpose of this study is to prospectively evaluated the T2* values of normal feti.A standardized scale of T2* values for fetal and neonatal iron organ overload have yet to be reported or devised.

NCT ID: NCT00980421 Not yet recruiting - Oxidative Stress Clinical Trials

Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children

Start date: October 2009
Phase: Phase 3
Study type: Interventional

The purpose of study is to evaluate and compare the effect of iron supplementation when given as iron tablet or fortified biscuit or combined with zinc in the form of tablet on morbidity and iron toxicity markers among children aged 24-36 months.