Iron Metabolism, Cystic Fibrosis Clinical Trial
Official title:
Prevalence and Incidence of Iron Deficiency in Cystic Fibrosis
Iron is a biologically essential micronutrient. Iron deficiency alters erythropoiesis and is
considered as a major cause of disability worldwide. Interestingly, iron overload is never
observed in cystic fibrosis contrarily to others chronic respiratory diseases. Moreover, iron
deficiency reported prevalence in CF is very high (up to 60% in retrospective series) and is
correlated to an alteration of respiratory function.
Cystic fibrosis patients should be tested annually for iron deficiency. Serum ferritin is the
best diagnosis tool for iron deficiency (specificity 87% for a threshold < 30 µg/L).
Previously published studies used less performant markers such as serum iron (< 12 µmol/L) or
transferrin saturation (< 12%), which are markedly influenced by the systemic inflammation.
CF patients experiences frequent pulmonary exacerbations leading to systemic inflammation:
iron stores should therefore be assessed at optimal time with no inflammation.
The I-MUCO study aims to determine the exact prevalence of iron deficiency in CF patients. We
aimed to identify risk factors for iron deficiency onset.
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