Iron Deficiency Clinical Trial
Official title:
Iron Absorption From Tef-injera in Women of Reproductive Age
Anemia is one of the most common health problems all over the world with around half of
preschool-aged children (<5 years) and one third of women affected. Nutritional iron
deficiency is a major reason for anemia in infants, young children and women of reproductive
age who have especially high iron requirements that are difficult to meet in regions where
the major diet is based on plant foods. So in Ethiopia, where injera is the major staple
food. Despite high levels of iron in tef, the most favored cereal for injera, the iron
bioavailability is assumed to be very low due to the high levels of phytic acid found in
tef.
The aim of this study is to determine the iron bioavailability in women from injera prepared
in a traditional way and investigate the potential of methods to improve the bioavaiability.
Therefore, a 50/50 and a 25/75 blend of FeSO4 and NaFeEDTA for iron fortification will be
evaluated. Further the potential positive impact of phytic acid reduction on the iron
bioavailability will be investigated. The phytic acid reduction will be achieved in two
different ways, by addition of whole grain wheat as source of phytase and addition of a
commercially available microbial phytase. The studies will be conducted in healthy women
using stable isotope techniques.
n/a
Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
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