Iron Deficiency Clinical Trial
Official title:
Effect of Dephytinisation of Fonio With Intrinsic Wheat Phytase on Iron Absorption in Beninese Women
The study sought to investigate the effect of lowering phytic acid in fonio porridge with phytase activity naturally occurring in wheat flour on iron absorption using labelled stable isotopes of iron. The study population is represented by 16 apparently healthy young Beninese women aged 18-30 years recruited based on their willingness to participate and according to inclusion criteria. Test meals consisted of fonio porridges fortified with isotopically labelled [57Fe] or [58Fe] ferrous sulfate with and without wheat flour. Meals were administered to fasting subjects on two consecutive days using a randomised crossover design: half the subjects received the test meal on the first day and the control on the second day and vice versa. Venous blood sample were collected (day 1 and day 14) for iron status and iron absorption measurement. Iron absorption measurement is based on erythrocyte incorporation of iron stable isotope labels 14 days after intake of the labelled test meals and calculated based on isotope-dilution.
Objective: To compare the bioavailability of iron in fonio porridge fortified with
isotopically enriched [57Fe] or [58Fe]-ferrous sulfate with and without reducing phytic acid
by native phytase in wheat flour.
Study population: Sixteen apparently healthy young women aged 18-30 years recruited at the
University based on their willingness to participate and according to inclusion criteria.
Study design: Fonio porridges fortified with isotopically labelled [57Fe] or [58Fe] ferrous
sulfate, with (test meal) and without wheat flour (control meal) are administered to fasting
subjects on two consecutive days using a randomised crossover design. Half the subjects
received the test meal on the first day and the control on the second day and vice versa. No
food or drink was allowed within the 3 hours after consumption. All meals were administered
under close supervision. Venous blood sample were collected (day 1 and day 16) for iron
status and iron absorption measurement. Iron absorption measurement is calculated based on
iron isotope-dilution in erythrocyte 14 days after intake of the labelled meals.
Study parameters: Fourteen days before the test, height and weight were measured for
nutritional status and subjects were screened for pregnancy and malaria. They were also
treated with antihelminth (albendazole tablet). The day before meals test (day 0), whole
blood sample was collected for hemoglobin (Hb), serum ferritin (SF), serum Transferrin
Receptor (sTfR) and C-reactive protein (CRP). Anemia and iron deficiency was defined as Hb <
120 g/L, and SF < 12 µg/L respectively. Pregnancy test and malaria tests were repeated on
that day. On day 1 and day 2, the fonio porridges were randomly given to the subjects on a
cross-over designed. Fourteen days after the meal test (day 16) whole blood sample was
collected for iron absorption measurement.
;
Observational Model: Case-Only, Time Perspective: Retrospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01483768 -
Study of Sleeve Gastrectomy on Iron Intestinal Absorption in Morbidly Obese Patients
|
N/A | |
Completed |
NCT02888171 -
Impact of Ferric Citrate vs Ferrous Sulfate on Iron Parameters and Hemoglobin in Individuals With CKD and Iron Deficiency
|
N/A | |
Recruiting |
NCT02242188 -
Supplementing Iron and Development in Breastfed Infants (SIDBI Study)
|
Phase 4 | |
Completed |
NCT02714361 -
A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
|
N/A | |
Completed |
NCT02176759 -
Iron Absorption From Rice Fortified With Ferric Pyrophosphate
|
N/A | |
Completed |
NCT01991626 -
Evaluation of the Effects of an Exogenous Phytase on Iron Absorption From LNS Added to Complementary Foods
|
N/A | |
Completed |
NCT01922479 -
Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure
|
Phase 4 | |
Completed |
NCT01687062 -
Iron Absorption From Tef-injera in Women of Reproductive Age
|
N/A | |
Completed |
NCT01573013 -
Iron Fortification Trail Using NaFeEDTA in Iron Deficient Lead-exposed Children
|
N/A | |
Completed |
NCT01191463 -
The Efficacy of a Local Vitamin-C Rich Fruit (Guava) in Improving Iron Absorption From Mungbean Based Meals and Its Effect on Iron Status of Rural Indian Children (6-10 Years)
|
N/A | |
Completed |
NCT01061307 -
An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand
|
Phase 0 | |
Not yet recruiting |
NCT00515918 -
The Effect of Early Iron Deficiency on Developmental Brain and Behavior in Infants
|
N/A | |
Recruiting |
NCT00378469 -
Study of the Effects of Muscular Activity on Iron Metabolism
|
N/A | |
Recruiting |
NCT05992116 -
Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction
|
||
Completed |
NCT05262634 -
Pregnancy Outcome in Women With an Iron Deficiency in the First Trimester
|
||
Completed |
NCT06080555 -
Bioequivalence Study of Ferric Carboxymaltose Injection in Participants With Iron Deficiency Anaemia
|
Phase 1 | |
Completed |
NCT04602247 -
Evaluation of Iron Bioavailability From Iron Chlorophyllin
|
N/A | |
Completed |
NCT02996786 -
Effects of Danggui Buxue Tang on Blood Biochemical Parameters in Male Recreational Runners
|
N/A | |
Completed |
NCT02175888 -
The Optimization of Bioavailability From Iron Supplements: Study 1
|
N/A | |
Completed |
NCT02222805 -
Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment
|
N/A |