Iron Deficiency Clinical Trial
Official title:
Absorption, Stable Isotope Appearance and NTBI Profile From NaFeEDTA and Ferrous Sulphate
Several iron compounds are used for fortification, including ferrous sulphate and NaFeEDTA.
The absorption profile of these may differ because of differences in their dissolution in
the gastrointestinal tract and in their interaction with dietary inhibitors of iron
absorption. As these differences might lead result in varying reactions in the blood stream,
the appearance rate of the stable iron isotope, hepcidin, non-transferrin-bound iron and
total iron in the plasma will be monitored over six hours in adult women. This is relevant
as a spike of absorbed iron may increase non-transferrin-bound iron and this could be
pro-oxidative or increase growth of pathogens. Hepcidin is a key mediator of iron absorption
and will help explain the potential differences in the plasma iron profile.
The use of stable iron isotope appearance curves to specifically detect the appearance of
small amounts of absorbed iron in the blood and distinguish between circulating body iron
and iron absorbed from the test meal was tested in a pilot study (EK 2008-23). This method
is now used in a bigger sample to test the differences in absorption profile of ferrous
sulphate, FePPi and NaFeEDTA given at fortification level with a meal.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01483768 -
Study of Sleeve Gastrectomy on Iron Intestinal Absorption in Morbidly Obese Patients
|
N/A | |
| Completed |
NCT02888171 -
Impact of Ferric Citrate vs Ferrous Sulfate on Iron Parameters and Hemoglobin in Individuals With CKD and Iron Deficiency
|
N/A | |
| Recruiting |
NCT02242188 -
Supplementing Iron and Development in Breastfed Infants (SIDBI Study)
|
Phase 4 | |
| Completed |
NCT02714361 -
A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
|
N/A | |
| Completed |
NCT02176759 -
Iron Absorption From Rice Fortified With Ferric Pyrophosphate
|
N/A | |
| Completed |
NCT01991626 -
Evaluation of the Effects of an Exogenous Phytase on Iron Absorption From LNS Added to Complementary Foods
|
N/A | |
| Completed |
NCT01922479 -
Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure
|
Phase 4 | |
| Completed |
NCT01687062 -
Iron Absorption From Tef-injera in Women of Reproductive Age
|
N/A | |
| Completed |
NCT01573013 -
Iron Fortification Trail Using NaFeEDTA in Iron Deficient Lead-exposed Children
|
N/A | |
| Completed |
NCT01443832 -
Iron Absorption From Iron-fortified Fonio Porridge: a Stable Isotope Study
|
Phase 0 | |
| Completed |
NCT01191463 -
The Efficacy of a Local Vitamin-C Rich Fruit (Guava) in Improving Iron Absorption From Mungbean Based Meals and Its Effect on Iron Status of Rural Indian Children (6-10 Years)
|
N/A | |
| Completed |
NCT01061307 -
An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand
|
Phase 0 | |
| Not yet recruiting |
NCT00515918 -
The Effect of Early Iron Deficiency on Developmental Brain and Behavior in Infants
|
N/A | |
| Recruiting |
NCT00378469 -
Study of the Effects of Muscular Activity on Iron Metabolism
|
N/A | |
| Recruiting |
NCT05992116 -
Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction
|
||
| Completed |
NCT05262634 -
Pregnancy Outcome in Women With an Iron Deficiency in the First Trimester
|
||
| Completed |
NCT06080555 -
Bioequivalence Study of Ferric Carboxymaltose Injection in Participants With Iron Deficiency Anaemia
|
Phase 1 | |
| Completed |
NCT04602247 -
Evaluation of Iron Bioavailability From Iron Chlorophyllin
|
N/A | |
| Completed |
NCT02996786 -
Effects of Danggui Buxue Tang on Blood Biochemical Parameters in Male Recreational Runners
|
N/A | |
| Completed |
NCT02175888 -
The Optimization of Bioavailability From Iron Supplements: Study 1
|
N/A |