Iron Absorption and Exercise

Iron Deficiency Anemia Clinical Trial

Official title:

Fractional Iron Absorption in Response to an Acute Bout of Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04079322
• Other study ID #: 2019.28633
• Status: Completed
• Phase: N/A
• Start date: August 22, 2019
• Est. completion date: December 4, 2019

Study information

• Verified date: February 2020
• Source: Florida State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: December 4, 2019
• Est. primary completion date: December 4, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Members of the Florida State University Cross Country team

• Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days

• Refrain from using vitamin or mineral supplements on the study days

Exclusion Criteria:

• Musculoskeletal injury that compromise the ability to exercise

Related Conditions & MeSH terms

• Anemia, Iron-Deficiency
• Iron Deficiency Anemia
• Iron-deficiency

Intervention

Other:
• Meal
Participants will consume a meal containing a stable iron isotope following exercise or rest.

Locations

Country	Name	City	State
United States	Florida State University	Tallahassee	Florida

Sponsors (1)

Lead Sponsor	Collaborator
Florida State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in fractional iron absorption	Stable iron isotopes	Red blood cells collected on day 0 and day 14
Secondary	Change in concentration of ferritin in ng/mL	Blood measure	Day 0 and day 14
Secondary	Change in concentration of soluble transferrin receptor in nmol/L	Blood measure	Day 0 and day 14
Secondary	Change in concentration of hemoglobin in g/L	Blood measure	Day 0 and day 14
Secondary	Change in concentration of hematocrit as %	Blood measure	Day 0 and day 14
Secondary	Change in concentration of hepcidin in ng/mL	Blood measure	Day 0 and day 14
Secondary	Change in concentration of IL-6 in pg/mL	Blood measure	Day 0 and day 14