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Clinical Trial Summary

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Agammaglobulinemia
  • Autoimmune Lymphoproliferative Syndrome
  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Common Variable Immune Deficiency
  • Common Variable Immunodeficiency
  • DiGeorge Syndrome
  • Granulomatous Disease, Chronic
  • Hemophagocytic Lymphohistiocytosis
  • Hyper-IgM
  • Immune Deficiency Disorders
  • Immune Dysregulatory Disorders
  • Immunologic Deficiency Syndromes
  • IPEX
  • Lymphohistiocytosis, Hemophagocytic
  • Lymphoproliferative Disorders
  • Severe Combined Immunodeficiency
  • Syndrome
  • Wiskott-Aldrich Syndrome
  • X-linked Agammaglobulinemia
  • X-linked Lymphoproliferative Syndrome

NCT number NCT01821781
Study type Interventional
Source Washington University School of Medicine
Contact
Status Recruiting
Phase Phase 2
Start date March 2013
Completion date March 2027

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