Invitro Fertilization Clinical Trial
Official title:
Value of Cabergoline and Low Dose Aspirin in Poor Responders Undergoing ICSI-ET Using Microdose GnRH Agonist Flare-Up-Protocol
Ovarian stimulation will be done using the Microdose flare-up regimen. The patient will
receive diluted doses of the GnRH agonist leuprolide acetate 40 µg, given subcutaneously
twice daily. Two days later, stimulation will be initiated by intramuscular (IM) injections
of HMG (Merional, IBSA, Germany) in a dose of 300 IU/day.
Follicular monitoring began from the ninth day of the cycle by serial vaginal ultrasonography
and measurement of serum E2 levels. IM injections of 10000 IU HCG (Choriomon; IBSA, Germany)
will be injected when at least 2 follicles 18 mm were observed on ultrasonography.
Oocytes willbe retrieved 36 hours after hCG injection using a 17-gauge aspiration needle
under transvaginal ultrasound guidance. The pelvis is evaluated with ultrasound to ensure
that there is no internal bleeding.
After fertilization was confirmed when two polar bodies and two pronuclear were observed
18-20 hours after insemination, one to three grade A embryos were transferred at day 3
fertilization.
The luteal phase support will be initiated from the day of oocyte retrieval for all patients
with (Cyclogest 400 mg, Actavis pharmaceutical, UK) vaginal suppositories per day till the
day of serum pregnancy test was done.
Status | Not yet recruiting |
Enrollment | 120 |
Est. completion date | September 2018 |
Est. primary completion date | August 2018 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 39 Years |
Eligibility |
Inclusion Criteria: 1. Patients with a history of one or more failed IVF cycles with three or less retrieved oocytes 2. No age limitation 3. Patients with an inadequate ovarian response in previous cycle 4. Low estradiol (E2) levels in response to ovarian stimulation in previous cycle 5. Lower number of retrieved oocytes in previous trials. Exclusion Criteria: 1. Severe male factor (azospermia) 2. Hydrosalpinx 3. History of endometriosis 4. Endocrine or metabolic disorders 5. Follicle stimulating hormone (FSH) level > 15 mIU. 6. Antimullerian hormone (AMH)< 0.5 ng/ml 7. Any uterine causes of infertility e.g. septate uterus |
Country | Name | City | State |
---|---|---|---|
Egypt | Kasr Alainy medical school | Cairo |
Lead Sponsor | Collaborator |
---|---|
Cairo University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | clinical pregnancy | Intrauterine gestational sac detection by transvaginal ultrasound | 4 weeks after embryo transfer |
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