Pneumatic Reduction For Intussusception In Children: A Retrospective

Status Completed

Clinical Trial Summary

In pediatric patients, intussusception predominantly occurs in the ileocecal region, with over 90% of cases lacking identifiable causative factors, initiating through peristalsis-driven invagination of bowel segments leading to compromised blood flow and subsequent bowel edema. Persistent obstruction may progress to bowel ischemia and infarction. Vietnam exhibits a higher incidence of intussusception compared to other countries, albeit with similar clinical presentations and anatomical locations, hinting at shared pathophysiology. Despite evidence supporting the safety and efficacy of non-surgical reduction techniques, many medical centers in low- to middle-income countries (LMICs) have not adopted these methods, resulting in unnecessary surgical interventions. The Vietnam National Hospital of Pediatrics (NCH) has employed air enema reduction since the early 2000s but lacks a comprehensive study on fluoroscopic-guided air-enema reduction (FGAR) techniques or success rates. Thus, this study aims to evaluate the long-term outcomes of pneumatic reduction for intussusception at NCH, a high-volume institution in a lower-middle-income country.

Clinical Trial Description

In pediatric patients, intussusception primarily occurs in the ileocecal region, with more than 90% of cases lacking identifiable causative factors. The invagination of bowel segments is propelled by peristalsis, leading to compromised blood flow. This venous occlusion precipitates bowel edema, and if the obstruction persists, it can progress to bowel ischemia and infarction. The incidence of intussusception in Vietnam exceeds that of any other country with available data on incidence rates. Despite variations in incidence rates, intussusception's clinical presentation and anatomical location remain largely consistent between Vietnam and other countries, suggesting a common underlying pathophysiology. Many medical centers in low- to middle-income countries (LMICs) have yet to adopt these non-surgical approaches, resulting in unnecessary surgical interventions for a significant portion of patients. At the Vietnam National Hospital of Pediatrics (NCH), air enema reduction has been a standard practice since the early 2000s. Nonetheless, there has been no comprehensive study delineating the technique of fluoroscopic-guided air-enema reduction (FGAR) at NCH, nor assessing its success rate. ;

Study Design

Related Conditions & MeSH terms

Intussusception

Clinical Trial Details

NCT number	NCT06365333
Study type	Observational
Source	National Children's Hospital, Vietnam
Contact
Status	Completed
Phase
Start date	January 2016
Completion date	April 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02052063` - Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ?	N/A
Completed	`NCT03185637` - Children's Surgery in Sub-Saharan Africa	N/A
Completed	`NCT00256984` - Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS)	Phase 4
Completed	`NCT02542462` - Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study	Phase 4
Completed	`NCT01479491` - Study on the Incidence of Intussusception (IS) in Children Aged < 12 Months in Japan	N/A
Completed	`NCT03360643` - Point-of-Care Ultrasonography for Intussusception	N/A
Completed	`NCT01177839` - Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore	N/A
Completed	`NCT04020939` - The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery.	N/A
Recruiting	`NCT04829032` - GOODBYE HARTMANN TRIAL: 100 YEARS OF HARTMANN'S PROCEDURE
Completed	`NCT05259670` - Risk Factors for Recurrent Intussusception Successful Reduction in Pediatric Patients
Not yet recruiting	`NCT04454320` - Seasonal Variations and Different Treatment Protocols of Intussusception in Children: Our Centers Experiences
Recruiting	`NCT05710913` - Development of Machine Learning Models for the Prediction of BMI and Complications After Bariatric Surgery (CABS-Study)
Completed	`NCT06351163` - Minimally Invasive Surgical Management for Pediatric Intussusception: A Retrospective Cohort Study
Completed	`NCT00673400` - Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM	N/A
Completed	`NCT04486300` - Seasonal Variations and Different Treatment Protocols OF Intussusception In Children:	N/A
Completed	`NCT00556283` - RCT: STARR vs Biofeedback	Phase 4
Recruiting	`NCT05640375` - Follow-up and Steroid Treatment Results in Intussusception	Phase 1/Phase 2
Recruiting	`NCT02691858` - Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception	N/A
Completed	`NCT00436358` - Implementing Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals in Mexico	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms