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NCT02844894 Clinical Trial

Hemodynamic Response to Intubation

Intubation Clinical Trial

Official title:
The Effects of Preintubation Esmolol and and Dexmedotimidine on Ischmeia Modified Albumin Levels

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02844894
Other study ID # RespToIntubation
Secondary ID
Status Recruiting
Phase Phase 4
First received July 22, 2016
Last updated July 25, 2016
Start date June 2016
Est. completion date September 2016

Study information
Verified date July 2016
Source Ufuk University
Contact Perihan Ekmekçi, Ass Prof
Phone +903122044000
Email erdogduperi@gmail.com
Is FDA regulated No
Health authority Turkey: Ministry of Health
Study type Interventional

Clinical Trial Summary

This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself. Half the patients will recevice dexmedetomidine and the other half will receive dexmedetomidine. Ischemia modified albumine levels will be measured

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date September 2016
Est. primary completion date August 2016
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Patients undergoing elective surgery under general anesthesia

Exclusion Criteria:

- Patient refusal

- Morbid obesity (BMI>30)

- Advanced systemic disease

- Hypoalbumiemia

- beta-blocker usage

- Anticipated difficult ventilation and/or intubation

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Intervention

Drug:
• Dexmedetomidine

• Esmolol

• Placebo
normal saline

Locations
Country Name City State
Turkey Ufuk University Hospital Ankara

Sponsors (1)
Lead Sponsor Collaborator
Ufuk University

Country where clinical trial is conducted

Turkey, 

References & Publications (1)

Yallapragada SV, Vidadala KS, Vemuri NN, Shaik MS. Comparison of the efficacy of dexmedetomidine with that of esmolol in attenuating laryngoscopic and intubation response after rapid sequence induction. Anesth Essays Res. 2014 Sep-Dec;8(3):383-7. doi: 10. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary ischemia modified albumine ischemia modified albumine levels will be measured as a response to intubation 10 minutes after endotracheal intubation No
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