The Study of Ciprofol for the Suppression of Cardiovascular Responses to

Status Recruiting

Clinical Trial Summary

Preliminary studies have illuminated the promising nature of ciprofol, indicating its enhanced safety spectrum, superior potency, and a diminished likelihood of experiencing injection-related discomfort. Venturing deeper, this research embarked on an ambitious quest to measure the 95% effective volume of ciprofol for induction of general anesthesia by a modified sequential method and juxtapose the 95% effective volume dosage of ciprofol against a corresponding dose of remimazolam during the initiation of general anesthesia. The study delved into diverse anesthetic protocols, meticulously scrutinizing the safety and efficacy credentials of ciprofol. The ultimate vision was to pave a robust foundation for the sophisticated and judicious utilization of ciprofol in clinical landscapes.

Clinical Trial Description

During general anesthesia induction, tracheal intubation is a significant procedure that can cause cardiovascular fluctuations due to the stimulation of tracheal receptors. This can lead to complications such as imbalances in vital organ oxygen supply, especially in patients with cardiovascular and cerebrovascular disorders, potentially resulting in cardiac arrest. As the demand for anesthetics rises in clinical settings, some, due to extreme side effects, have been phased out, reducing the available options. Propofol, a common anesthetic, is effective and quick but has drawbacks like injection pain and risks associated with long-term use. In contrast, ciprofol, a new class I intravenous anesthetic, is emerging as a potentially better alternative. Early research indicates that ciprofol might have a broader safety margin than propofol and offers benefits like rapid recovery and lower chances of injection pain. Exhaustive studies on the precise dosage of ciprofol for surgical applications are scarce and comparisons between ciprofol and remimazolam are rarely reported in the literature. This research aims to bridge this knowledge gap, exploring the best dosage for tracheal intubation sedation, and ensuring patients get the most effective and safest anesthetic care. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06095570
Study type	Interventional
Source	The Second Affiliated Hospital of Hainan Medical University
Contact	Hu Sun
Phone	13617518996
Email	sunhu09@163.com
Status	Recruiting
Phase	Phase 4
Start date	July 23, 2022
Completion date	December 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04994652` - Video- Or Direct Laryngoscopy for Endotracheal Intubation in Newborns	N/A
Completed	`NCT03301324` - Intubation Assist Clinical Study	N/A
Not yet recruiting	`NCT05534451` - Comparison Among Three Different Video Scope Guided Nasotracheal Intubation.	N/A
Not yet recruiting	`NCT04116333` - Effect of Using Endotracheal Tube Introducer for Intubation During Mechanical Chest Compressions in a Manikin	N/A
Recruiting	`NCT02001285` - Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation	N/A
Completed	`NCT02034643` - Transesophageal Echocardiography(TEE) Probe Insertion and Tracheal Cuff Pressure	N/A
Completed	`NCT01718561` - The Difficult Airway Management Trial: "The DIFFICAIR-Trial"	N/A
Completed	`NCT01227486` - Verification of Endotracheal Tube Placement by Ultrasound in the Obese Patient	N/A
Withdrawn	`NCT01252173` - Measurement Of Endotracheal Tube Cuff Pressure In Emergency Department Patients	N/A
Completed	`NCT04591769` - Tracheal Tube Cuff Shape and Pressure	N/A
Completed	`NCT03841890` - The Clarus Video System and Direct Laryngoscope for Rapid Sequence Induction Intubation With Cricoid Pressure	N/A
Recruiting	`NCT03716713` - CeraShield™ Endotracheal Tube Feasibility Study	N/A
Not yet recruiting	`NCT03938506` - The Assessment of the Pilot Balloon Palpation Method in Different-sized Endotracheal Tubes
Not yet recruiting	`NCT01974505` - Learning Curve of Optiscope by Anesthesia Providers	N/A
Completed	`NCT06107998` - Comparison of Different Methods for Determining Endotracheal Cuff Pressure	N/A
Completed	`NCT02822846` - Evaluation of the Ability to Diagnose the Position of the Intubation Probe Thanks to Lung Ultrasonography
Completed	`NCT03116373` - Impact of Tracheal Tube Fixing Site on Its Mobility During Head Mobilization	N/A
Completed	`NCT02423317` - Comparison of Miller's Blade and Airtraq Laryngoscope in Children	N/A
Not yet recruiting	`NCT04872881` - Comparison of Effectiveness of Different Airway Management Methods During Percutaneous Tracheostomy	Phase 4
Completed	`NCT04863846` - Evidence-based Algorithm for the Expected Difficult Intubation

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms