Clinical Trials Logo
  1. Home
  2. Intubation, Intratracheal
  3. NCT03612921

Oral Amantadine, IV Amantadine and Hemodynamic Response to Laryngoscopy

Intubation, Intratracheal Clinical Trial

Official title:
Oral Amantadine Versus IV Amantadine to Attenuate the Hemodynamic Response to Laryngoscopy, Tracheal Intubation and Surgical Incision and Their Effect on β-endorphin: A Randomized Clinical Trial

Clinical Trial Summary

this study will be undertaken-to evaluate the effect of oral amantadine versus IV amantadine premedication on the hemodynamic response to laryngoscopy ,tracheal intubation and surgical incision and their effect on β-endorphins.

Clinical Trial Description

Direct laryngoscopy and passage of endotracheal tube through the larynx is a noxious stimulus, which can provoke untoward response in the cardiovascular, respiratory and other physiological systems .Amantadine is a non-competitive NMDA receptor antagonist, and compared to ketamine, it is well tolerated with fewer side effects (mainly dizziness, sedation, and dry mouth). Amantadine's formulation permits the oral route for drug delivery, as well as the IV route. The side-effects profile of amantadine via all routes seems not to be harmful in appropriate dosages.. Amantadine has been clinically used as an antiviral drug, for dementia, and in the treatment of Parkinson's disease and spasticity. It is a non-competitive NMDA receptor antagonist, and compared to ketamine, it is well tolerated with fewer side effects (mainly dizziness, sedation, and dry mouth). Amantadine's formulation permits the oral route for drug delivery, as well as the IV route. The side-effects profile of amantadine via all routes seems not to be harmful in appropriate dosages. In the central nervous system, beta-endorphins bind mu-opioid receptors and exert their primary action at presynaptic nerve terminals. However, instead of inhibiting substance P, they exert their analgesic effect by inhibiting the release of GABA, an inhibitory neurotransmitter, resulting in excess production of dopamine. this study will be undertaken-to evaluate the effect of oral amantadine versus IV amantadine premedication on the hemodynamic response to laryngoscopy ,tracheal intubation and surgical incision and their effect on β-endorphins. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03612921
Study type Interventional
Source Assiut University
Contact Ghada Abu El Fadl, MD
Phone 01005802086
Email ghadafadl77@gmail.com
Status Recruiting
Phase Phase 2
Start date August 15, 2018
Completion date April 1, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT04994652 - Video- Or Direct Laryngoscopy for Endotracheal Intubation in Newborns N/A
Completed NCT03301324 - Intubation Assist Clinical Study N/A
Not yet recruiting NCT05534451 - Comparison Among Three Different Video Scope Guided Nasotracheal Intubation. N/A
Not yet recruiting NCT04116333 - Effect of Using Endotracheal Tube Introducer for Intubation During Mechanical Chest Compressions in a Manikin N/A
Recruiting NCT02001285 - Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation N/A
Completed NCT02034643 - Transesophageal Echocardiography(TEE) Probe Insertion and Tracheal Cuff Pressure N/A
Completed NCT01718561 - The Difficult Airway Management Trial: "The DIFFICAIR-Trial" N/A
Completed NCT01227486 - Verification of Endotracheal Tube Placement by Ultrasound in the Obese Patient N/A
Withdrawn NCT01252173 - Measurement Of Endotracheal Tube Cuff Pressure In Emergency Department Patients N/A
Completed NCT04591769 - Tracheal Tube Cuff Shape and Pressure N/A
Completed NCT03841890 - The Clarus Video System and Direct Laryngoscope for Rapid Sequence Induction Intubation With Cricoid Pressure N/A
Recruiting NCT03716713 - CeraShield™ Endotracheal Tube Feasibility Study N/A
Not yet recruiting NCT03938506 - The Assessment of the Pilot Balloon Palpation Method in Different-sized Endotracheal Tubes
Not yet recruiting NCT01974505 - Learning Curve of Optiscope by Anesthesia Providers N/A
Completed NCT06107998 - Comparison of Different Methods for Determining Endotracheal Cuff Pressure N/A
Completed NCT02822846 - Evaluation of the Ability to Diagnose the Position of the Intubation Probe Thanks to Lung Ultrasonography
Completed NCT03116373 - Impact of Tracheal Tube Fixing Site on Its Mobility During Head Mobilization N/A
Completed NCT02423317 - Comparison of Miller's Blade and Airtraq Laryngoscope in Children N/A
Completed NCT04863846 - Evidence-based Algorithm for the Expected Difficult Intubation
Not yet recruiting NCT04872881 - Comparison of Effectiveness of Different Airway Management Methods During Percutaneous Tracheostomy Phase 4