Impact of a Intra-tracheal Intubation With Curarization or Without

Status Terminated

Clinical Trial Summary

VHIntubation is a French monocentric and observational study that will assess the impact of two intra-tracheal intubation preparation procedures (curarization versus remifentanil) on the voice, using the Voice Handicap Index (VHI) self-questionnaire.

Clinical Trial Description

Some surgeries are known to expose patients to voice disorders (thyroidectomy, parathyroidectomy, carotid surgery…). However, voice disorders can be due, among other things, to a laryngeal nerves alteration and intubation trauma. Our team has published 2 prospective studies on the frequency of voice troubles after thyroidectomy (Borel et al. Surgery 2018 and 2019). To limit post tracheal intubation voice troubles , it is generally recommended to practice intra-tracheal intubation with a curarization (Lundstrøm et al. Br J Anaesth 2018). However, for few years, the very vast majority of thyroid surgery is practiced with a neuromonitoring of laryngeal nerves (NIM). NIM ensures prosper functioning of the vocal cords intra- and post-operatively with an excellent negative predictive value (>98%, Mirallié et al. Surgery 2018). However, the use of NIM requires an absence of curarization. Some centres, including ours, have abandoned systematic curarization before intubation for thyroidectomy; other centres continue to practice curarization with, sometimes, the need to antagonize curarization for an effective NIM utilization. The aim of this study is to assess the impact of intubation preparation procedures (curarization versus remifentanil) on the voice using Voice Handicap Index (VHI) questionnaire. The Nantes University Hospital is the sponsor of " REMICRUSH ", study on " Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant. A Non-inferiority Simple Blind Randomized Controlled Trial ", the coordinator of which is Dr Nicolas Grillot. This study began in October 2019 and authorisations are obtained. We aim to propose our study " VHIntubation " to patients participating in REMICRUSH in order to benefit from REMIFENTANIL versus CURARE randomization. ;

Study Design

Related Conditions & MeSH terms

Intubation Complication

Clinical Trial Details

NCT number	NCT04364633
Study type	Observational
Source	Nantes University Hospital
Contact
Status	Terminated
Phase
Start date	June 16, 2020
Completion date	December 31, 2020

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT05717907` - Suction Catheter as a Guide for Nasotracheal Intubation Under General Anesthesia	N/A
Completed	`NCT03653910` - Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope	N/A
Recruiting	`NCT04190524` - Sonographic Assessment of Cricoid Pressure	N/A
Completed	`NCT02359370` - The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation	Phase 4
Not yet recruiting	`NCT05036460` - Real-time Sonography in Detecting Inadvertent Esophageal Intubation Among Difficult Intubation Patients	N/A
Completed	`NCT05502120` - A Comparison of Vie-Scope and Macintosh Blade Laryngoscopes in Morbidly Obese.	N/A
Completed	`NCT03992950` - Effectiveness of Cricoid and Paratracheal Pressures for Occluding Esophagus	N/A
Completed	`NCT05303948` - Evaluation of Two Positions for Free Floating Tracheal Intubation in Weightlessness	N/A
Completed	`NCT03720093` - Exploratory Analysis of Pulmonary Microbiome in Intubated Patients
Recruiting	`NCT03031808` - Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant on Sore Throat and Hemodynamics	Phase 4
Not yet recruiting	`NCT02918526` - Hemodynamic Study With PRAM of the Cardiovascular Response to the Positioning of the Extraglottic Device	N/A
Completed	`NCT02364622` - The Effects of Flexible Intubating Stylet in the Accurate Placement of Double-lumen Endobronchial Tube	N/A
Completed	`NCT05249738` - Tongue Edema Caused by Intubation Tube in Intensive Care Unit Patients
Terminated	`NCT03340207` - Novel Airway Device to Aid Endotracheal Intubations	N/A
Completed	`NCT03842306` - End-tidal Oxygen Can Reliably Predict the Arterial Partial Pressure of Oxygen Among Emergency Department Patients
Recruiting	`NCT05782517` - I-gel vs. Endotracheal Intubation for Laparoscopic Gynaecological Procedures	N/A
Recruiting	`NCT06085326` - Smart Checklist Implementation for Pediatric Tracheal Intubations in the ICU- Multicenter Study	N/A
Active, not recruiting	`NCT06108271` - Innovative Endotracheal Tube Design Reduces Postoperative Laryngeal Injury	N/A
Completed	`NCT05668299` - Determining the Appropriate Setting of an Automated Secretion Removal Technology (TrachFlush)	N/A
Completed	`NCT04079387` - Effect of Endotracheal Tube Plus STYLET Versus Endotracheal Tube Alone	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Impact of a Intra-tracheal Intubation With Curarization or Without Curarization — VHIntubation

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms