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Clinical Trial on Treatment of Intraventricular Hemorrhage — CLEAR IVH  

Intraventricular Hemorrhage Clinical Trial

Official title:
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage (IVH)

Clinical Trial Summary

The specific objective of this trial is to determine the lowest dose and dose frequency possible with the best pharmacokinetic and safety profile and it's ability to remove a blood clot from the ventricular system.

Clinical Trial Description

The purpose of this trial is to determine the efficacy and pharmacokinetics of intraventricular injections of multiple low doses of rt-PA. Sixteen subjects were already randomized to receive intraventricular injections of with 0.3 mg or 1.0 mg of rt-PA every 12 hours for up to 8 doses. Results of this stage (n=16) were then analyzed and the most effective dose of 1.0 mg was chosen to be used in the second stage (n=36) to determine the optimal frequency of dosing. We propose to test if this intervention facilitates more rapid clot resolution, complete recovery function and decreased mortality from this condition. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00650858
Study type Interventional
Source Johns Hopkins University
Contact
Status Completed
Phase Phase 2
Start date February 2004
Completion date August 2008
View Details
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