The Effect of Antenatal Corticosteroid on Umbilical Artery Doppler Velocimetry in IUGR

Intrauterine Growth Restriction Clinical Trial

Official title:

The Effect of Antenatal Corticosteroid Administration on Umbilical Artery Doppler Velocimetry in Pregnant Women Complicated With IUGR

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05588986
• Other study ID #: Antenatal-IUGR
• Status: Completed
• Start date: February 2, 2018
• Est. completion date: February 2, 2019

Study information

• Verified date: July 2023
• Source: Kocaeli University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate the effect of antenatal corticosteroid administration on umbilical artery Doppler velocimetry measurements in pregnancies complicated by IUGR.

Description:

This study was conducted with pregnant women who were likely to have preterm birth and were treated with antenatal corticosteroids. Betamethasone was used as an antenatal corticosteroid. UA Doppler measurements (PI, S/D ratio, RI) before antenatal corticosteroid administration and 24 and 48 hours after the last dose of corticosteroid administration were evaluated in pregnant groups complicated with IUGR and uncomplicated with IUGR and compared with each other.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 149
• Est. completion date: February 2, 2019
• Est. primary completion date: September 2, 2018
• Gender: Female
• Age group: 18 Years to 49 Years

Eligibility

Inclusion Criteria:

pregnant women who were likely to have preterm delivery and were treated with antenatal corticosteroids.

Exclusion Criteria:

Pregnant women who had complicated pregnancy with fetal anomaly, who had multiple pregnancies, who left their pregnancy follow-up unfinished, and those under 18 years of age were excluded from the study.

Related Conditions & MeSH terms

• Fetal Growth Retardation
• Intrauterine Growth Restriction

Intervention

Other:
• ultrasonography
Umbilical artery Doppler evaluation by ultrasonography just before the first dose of antenatal corticosteroid, 24 hours and 48 hours after the last dose.

Locations

Country	Name	City	State
Turkey	Merve Demir	Kocaeli

Sponsors (2)

Lead Sponsor	Collaborator
Merve Demir	Marmara University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	systolic:diastolic ratio (S/D ratio)	Peak systolic velocity/end diastolic velocity	2018-2019
Primary	pulsatility index (PI)	Pulsatility Index (PI) = (Peak systolic velocity - end diastolic velocity)/(time averaged maximum velocity)	2018-2019
Primary	Resistive Index (RI)	Resistive Index (RI) = (Peak systolic velocity - end diastolic velocity)/(peak systolic velocity)	2018-2019