Pregnancy Clinical Trial
Official title:
Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight
The aim of this prospective longitudinal study was to investigate the relationship between placental thickness during the second and third trimesters and placental and birth weights.
The investigator will make certain that the appropriate informed consent process is in place
to ensure that potential research subjects, or their authorized representatives, are fully
informed about the nature and objectives of the study, the potential risk and benefits of
study participation, and their right as research subjects.
All laboratory specimens, evaluation forms, reports, video recordings, and other records
that leave the site will not include unique personal data to maintain subject
confidentiality.
All patients provided an informed written consent after they were fully instructed about the
investigation.The study was approved by ethical committee of Ain Shams University.
All recruited women were observed at the 1st trimester screening at antenatal clinic and
assessed for baseline demographic and obstetric data including age, parity, body mass index
(BMI) and past medical events. Smoking, alcohol and drug use were also determined.
At second and third trimester (15-20 and 30-34 weeks of gestation respectively), the
maternal weight, weight gain, BMI, BMI gain and data of ultrasound examination were
recorded. At the time of delivery after assessment of maternal weight as mentioned above,
the birth weight (in grams), fetal sex, and mode of delivery were taken.
All pregnant women underwent ultrasound evaluation of placental thickness at the time of
second trimester (15-20 weeks of gestation) as well as third trimester (30-34 weeks of
gestation).
All sonographic examinations were performed trans-abdominal using a Medison X4 ultrasound
machine Trans abdominal4.0 megahertz (MHz) probe at The Special Care Center for Fetus Unit
at Ain Shams University Maternity Hospital.
The placental thickness was measured by placing the ultrasound transducer perpendicularly to
the plane of the placenta, in the area of the cord insertion, near the mid-placental portion
as described by Hoddick et al.12.
Each evaluation was performed by one of two experienced sonographers of our hospital with
minimum inter- and intra-observer variability.
After delivery, the placenta was weighed in grams as previously described by Azpurua et
al.2.
Fetal weight (primary objective) and neonatal status and morbidity including baby Apgar
scores, fetal distress or fetal death and admission to the neonatal intensive care unit were
also determined. All the examinations and data recording were performed by two senior
resident physicians.(secondary objective)
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Observational Model: Cohort, Time Perspective: Prospective
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