Intrauterine Growth Restriction Clinical Trial
Official title:
MRI Assessment of Placental Health
The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR. In placenta related IUGR pregnancies, there can be multiple concurrent placental pathologies. Although there is no specific correspondence between a single type of pathology and IUGR, the common result of these pathologies is placental insufficiency, which limits the maternal-fetal exchange. Oxygen and nutrition transport is known to be hindered in IUGR placentas due to obstructed or abrupt vasculature, massive fibrin deposition, and inflammation in the villous and intervillous space (villitis). Thus one potential approach to distinguish IUGR pregnancies from normal ones is to assess the efficiency of placental transport. Based on the hypothesis that efficiency of oxygen transport is representative for overall oxygen and nutrition transport in placenta, the investigators propose to characterize the blood oxygenation and blood perfusion in placenta in vivo via MRI, and use it as an index for better stratification in the IUGR risk group. The investigators will also consider alternative MRI approaches such as structural, diffusion and spectroscopy measurements inside the placenta, which might reflect the state of placental transport and reveal the status of placental health. Specific aims: 1) To correlate the MRI metrics that differentiate placental insufficiency from normal placenta transport with histopathology data of the placenta. 2) To correlate the MRI metrics that reflects placental insufficiency with fetal outcome
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04506970 -
Predicting Placental Pathologies by Ultrasound Imaging
|
||
Recruiting |
NCT03866863 -
Intra Uterine Growth Restriction
|
||
Recruiting |
NCT03662178 -
Investigating the Structured Use of Ultrasound Scanning for Fetal Growth
|
||
Not yet recruiting |
NCT05720169 -
Fetal, Obstetrics and Reproduction Genomics
|
||
Completed |
NCT04633551 -
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
|
N/A | |
Recruiting |
NCT05500989 -
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
|
||
Recruiting |
NCT04141189 -
Comparison of Follow-up Protocols in Terms of Fetal, Neonatal and Maternal Results in Intrauterine Growth Retardation
|
N/A | |
Completed |
NCT03726697 -
Effect of Tahneek on Hypoglycemia in Newborn Infants
|
N/A | |
Recruiting |
NCT03398629 -
Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies
|
||
Recruiting |
NCT02473991 -
Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight
|
N/A | |
Completed |
NCT02696577 -
The Effect of Omega 3 on Pregnancy Complicated by Asymmetrical Intrauterine Growth Restriction
|
Phase 2 | |
Recruiting |
NCT04766866 -
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
|
N/A | |
Terminated |
NCT04047966 -
Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect Growth
|
||
Not yet recruiting |
NCT03865628 -
Ultrasound Evaluation of Fetal Hemodynamics and Perinatal Complications
|
||
Completed |
NCT05328453 -
Sonographic 3D Measurement of Fetal Thymus May be Used to Predict the Small Baby in Pregnancy.
|
||
Completed |
NCT05800938 -
The Effect of Oral Isosorbide Mononitrate Therapy on Umbilical Artery Doppler Resistance Index in Pregnancies With Intrauterine Growth Restriction: Prospective Randomized Control Trial
|
Phase 4 | |
Not yet recruiting |
NCT06226051 -
Growing Little PEAPODS Study
|
||
Recruiting |
NCT02807324 -
Women Specific Cardiac Recovery After Preeclampsia
|
||
Recruiting |
NCT02515292 -
Evaluation of Infants With Intrauterine Growth Restriction
|
N/A | |
Active, not recruiting |
NCT01942525 -
Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
|
N/A |