Intrauterine Adhesion Clinical Trial
Official title:
Evaluation of Adhesions Formation Using Conventional Third Generation Endometrial Ablation With and Without Postoperative Application of an Intrauterine Adhesion Barrier Film
Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier.
The application of endometrial ablation (EA) has significantly increased in the past 10 years. It is an effective treatment for heavy menstrual bleeding with functional aetiology. However, the risk of post-ablative intracavitary scarring after EA is significant and can lead to long term complications, and the possible delay in diagnosing endometrial cancer. CLEAN is a prospective, multi-center, randomized, controlled, two arm pilot clinical trial. The objective is to compare the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier. The study will be performed on women with heavy menstrual bleeding (menorrhagia) scheduled for thermal endometrial ablation with Novasure system (Hologic) A follow-up diagnostic hysteroscopy will be performed 4-8 weeks after the ablation procedure to determine the presence and severity of IUAs according to the American Fertility Society. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04972032 -
Efficacy of Estrogen-intrauterine Stent System After Intrauterine Adhesiolysis
|
N/A | |
Recruiting |
NCT03381807 -
Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion
|
Early Phase 1 | |
Recruiting |
NCT03329898 -
Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion
|
N/A | |
Completed |
NCT03724617 -
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
|
N/A | |
Recruiting |
NCT03330873 -
The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome
|
N/A | |
Completed |
NCT02220621 -
Efficacy and Safety of Crosslinked Hyaluronan Gel for Preventing Intrauterine Adhesion
|
N/A | |
Active, not recruiting |
NCT04963179 -
PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film.
|
N/A | |
Recruiting |
NCT03351205 -
The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis
|
N/A | |
Completed |
NCT04381728 -
PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film
|
N/A | |
Recruiting |
NCT03346317 -
Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
|
N/A | |
Completed |
NCT04166500 -
Early Outpatient Hysteroscopy Can Prevent Intrauterine Adhesion After Induced Abortion
|
N/A | |
Recruiting |
NCT03169478 -
Intrauterine Balloon Dilatation Therapy in the Prevention of Adhesion Formation After Hysteroscopic Myomectomy
|
N/A | |
Recruiting |
NCT03171454 -
Immediate and Delayed Intrauterine Balloon in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
|
N/A | |
Recruiting |
NCT05003869 -
Clinical and Basic Research on the Necessity of Scar Tissue Resection During Intrauterine Adhesions
|
N/A | |
Completed |
NCT02744716 -
Effects of Aspirin on Uterine Endometrial Repair Severe Intrauterine Adhesion
|
N/A | |
Completed |
NCT03131596 -
Postoperative Intermittent Intrauterine Balloon Dilatation Therapy.
|
N/A | |
Completed |
NCT04824430 -
Assessment of Uterine Access, Uterine Patency and Intrauterine Adhesions Following Endometrial Ablation
|
||
Completed |
NCT01167296 -
Safety of Leaving Cook Balloon Uterine Stent in Uterus for One Month
|
Phase 4 | |
Completed |
NCT03578172 -
HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients
|
N/A | |
Recruiting |
NCT04930913 -
Three-dimensional Ultrasound Applying in Assessment of Intrauterine Adhesions
|