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REmimazolam vs PrOpofol on Intraoperative hypotenSion in Major Noncardiac surgEry — REPOSE-1  

Intraoperative Hypotension Clinical Trial

Official title:
Effects of Total Intravenous Anesthesia With Remimazolam vs Propofol on Intraoperative Hypotension in Major Noncardiac Surgery: a Randomized Controlled Trial

Clinical Trial Summary

Intraoperative hypotension is common during major noncardiac surgery and is associated with adverse postoperative outcomes. Propofol, the most commonly used intravenous anesthetic agent worldwide, is associated with hypotension on induction and maintenance of general anesthesia. Remimazolam is a newly developed short-acting benzodiazepine drug and has been approved for use in procedural sedation and general anesthesia. It was associated with a lower incidence of hypotension during procedural sedation in previous studies. The aim of this study is to tested the primary hypothesis that total intravenous anesthesia with remimazolam reduces the duration and severity of hypotension during major noncardiac surgery compared with total intravenous anesthesia with propofol.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05436522
Study type Interventional
Source Nanfang Hospital of Southern Medical University
Contact Bingcheng Zhao, MD
Phone +8613763313653
Email zhaobch@mail2.sysu.edu.cn
Status Recruiting
Phase Phase 4
Start date August 22, 2022
Completion date August 2023
View Details
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