Intraoperative Bleeding Clinical Trial
Official title:
The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women: A Randomized Controlled Trial
NCT number | NCT03820206 |
Other study ID # | 50 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | January 31, 2019 |
Est. completion date | January 2, 2020 |
Verified date | January 2020 |
Source | Cairo University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
A full medical history will be obtained from all participants. Obstetric ultrasonography and
laboratory tests will be performed.According to group assignment, either 1 g(10 mL)
tranexamic acid stored in a dry container at 15 °C-30 °C) diluted in 20 mL of 5% glucose or
30 mL of 5% glucose will be slowly administered intravenously 15 minutes before skin incision
over a 5-minute period.
Following delivery, patients in both groups will receive an intravenous bolus of 5 IU
oxytocin , 1 mL(0.2 mg) intramuscular ergometrine , and 20 IU oxytocin in 500 mL lactated
Ringer's solution(infused at a rate of 125 mL/h)
Status | Completed |
Enrollment | 160 |
Est. completion date | January 2, 2020 |
Est. primary completion date | November 15, 2019 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - • Grand multipara - Multiple pregnancy - Polyhydraminos (AFI is more than 24 cm). - Placenta previa - Gestational diabetes mellitus - Preeclampsia - Anemia complicating pregnancy (Hemoglobin is less than 11 gm/dl) Exclusion Criteria: - • Allergy to tranxemic acid. - H/o suggestive of bleeding disorders - previous history of deep vein thrombosis - Abnormally invasive placenta - Emergency cesarean sections - Intraoprative complications during cesarean sections as uterine artery injury and broad ligamentary hematoma. |
Country | Name | City | State |
---|---|---|---|
Egypt | Kasr Alainy medical school | Cairo |
Lead Sponsor | Collaborator |
---|---|
Cairo University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Estimated blood loss (EBL) during cesarean delivery | EBL will be calculated according to the formula: EBL = EBV x Preoperative hematocrit-Postoperative hematocrit Preoperative hematocrit where EBV is estimated blood volume (mL; weight in kg × 85) |
during the operation |
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