Intraocular Pressure Clinical Trial
Official title:
The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients, Pressure Control and Pupil Effects
Verified date | July 2020 |
Source | Wake Forest University Health Sciences |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or after dilating the pupils will help to control the changes in intraocular pressure often seen when using dilating drops. The study will also evaluate the effects of different sequences of administering dilating drops along with Brimonidine on pupil size and reactivity.
Status | Completed |
Enrollment | 13 |
Est. completion date | July 20, 2019 |
Est. primary completion date | July 20, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Healthy individuals - Females of childbearing potential must agree to use a reliable method of birth control while participating in the study. Exclusion Criteria: - Diabetic - Have a history of glaucoma - Have a history of iris trauma - Have a history of eye surgery except for LASIK or PRK - Pregnant - Anisocoria (unequal pupils) |
Country | Name | City | State |
---|---|---|---|
United States | Wake Forest Baptist Medical Center | Winston-Salem | North Carolina |
Lead Sponsor | Collaborator |
---|---|
Wake Forest University Health Sciences |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Intraocular Pressure | To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure. | Baseline (Pre drop administration) | |
Primary | Intraocular Pressure | To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure. | 15 minutes post drop administration | |
Primary | Intraocular Pressure | To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure. | 30 minutes post drop administration | |
Primary | Intraocular Pressure | To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure. | 1 hour post drop administration | |
Primary | Intraocular Pressure | To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure. | 2 hour post drop administration | |
Primary | Intraocular Pressure | To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure. | 4 hour post drop administration | |
Secondary | Pupil Size | Pupil size measurement | Baseline (Pre drop administration) | |
Secondary | Pupil Size | Pupil size measurement. | 15 minutes post drop administration | |
Secondary | Pupil Size | Pupil size measurement | 30 minutes post drop administration | |
Secondary | Pupil Size | Pupil size measurement. | 1 hour post drop administration | |
Secondary | Pupil Size | Pupil size measurement. | 2 hours post drop administration | |
Secondary | Pupil Size | Pupil size measurement | 4 hours post drop administration | |
Secondary | Pupil Reaction to Light | Pupil reaction to light will be measured as none (0), poor (1) or brisk (2). | Baseline (Pre drop administration) | |
Secondary | Pupil Reaction to Light | Pupil reaction to light will be measured as none (0), poor (1) or brisk (2). | 15 minutes post drop administration | |
Secondary | Pupil Reaction to Light | Pupil reaction to light will be measured as none (0), poor (1) or brisk (2). | 30 minutes post drop administration | |
Secondary | Pupil Reaction to Light | Pupil reaction to light will be measured as none (0), poor (1) or brisk (2). | 1 hour post drop administration | |
Secondary | Pupil Reaction to Light | Pupil reaction to light will be measured as none (0), poor (1) or brisk (2). | 2 hours post drop administration | |
Secondary | Pupil Reaction to Light | Pupil reaction to light will be measured as none (0), poor (1) or brisk (2). | 4 hours post drop administration |
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