Intraocular Pressure Clinical Trial
Official title:
The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients, Pressure Control and Pupil Effects
This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or after dilating the pupils will help to control the changes in intraocular pressure often seen when using dilating drops. The study will also evaluate the effects of different sequences of administering dilating drops along with Brimonidine on pupil size and reactivity.
Intraocular pressure (IOP) can fluctuate due to various external factors such as exercise, medications, and eye movements. Although it is considered natural for IOP to fluctuate daily, prolonged increases in IOP can be harmful. Sustained elevated IOP has been linked to optic nerve damage and glaucoma. Mydriatic drops routinely given to dilate pupils in patients in need of an eye exam have been known to increase IOP. In practice, a combination of drugs are used to achieve pupil dilation needed for routine eye exams or in perioperative situations. The use of Tropicamide 1% and Phenylephrine 2.5% are known to be safe and effective options for dilating the pupils when used in conjunction with one another, but these drugs can increase IOP. Drugs such as Brimonidine, a selective alpha-2 agonist, are known to reduce IOP through several different methods. This study seeks to understand the effects of Brimonidine used along with Tropicamide and Phenylephrine to control IOP. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03494257 -
Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification
|
N/A | |
Completed |
NCT03016234 -
IOP Changes With Different Anesthetic Agents During Laparoscopic Colorectal Surgery
|
N/A | |
Completed |
NCT04863209 -
Effect of Osteopathic Techiniques on Intraocular Pressure
|
N/A | |
Completed |
NCT03139708 -
The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients
|
Phase 1 | |
Completed |
NCT02646033 -
Quantitative Rise in Intraocular Pressure in Steep Trendelenburg Position
|
||
Recruiting |
NCT02697825 -
Intraocular Pressure Versus Optic Nerve Sheath Diameter
|
N/A | |
Completed |
NCT02985567 -
An Observational Study of the Use of Chloral Hydrate for Ophthalmic Procedures in Children
|
N/A | |
Withdrawn |
NCT00837226 -
Effects of Weight Loss From Bariatric Surgery on Intraocular Pressure (IOP)
|
N/A | |
Completed |
NCT02136589 -
Effect of NSAID on Travoprost-induced Conjunctival Hyperemia and IOP Reduction in Normal Eyes
|
Phase 4 | |
Completed |
NCT03123614 -
Loteprednol vs. Prednisolone and Fluorometholone
|
Phase 4 | |
Completed |
NCT05763056 -
Effects of Intubation on Intra-ocular Pressure and Optic Nerve Sheath Diameter
|
N/A | |
Completed |
NCT03359200 -
Analysis of the Microbiota in Goldmann Applanation Tonometers at a Reference Service in Goiânia
|
N/A | |
Withdrawn |
NCT02558309 -
Optic Nerve Head Quantification While Reducing Elevated Intracranial Pressure
|
N/A | |
Completed |
NCT02816905 -
Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery
|
Phase 4 | |
Completed |
NCT01786954 -
iCare vs Tonopen vs Goldmann Applanation Post-vitrectomy Surgery
|
N/A | |
Completed |
NCT00552019 -
Intraocular Pressure (IOP) Assessed by Dynamic Contour Tonometer (DCT) and Goldman Applanation Tonometry (GAT)
|
N/A | |
Completed |
NCT00428740 -
Long-Term IOP Fluctuation and VF Progression After Triple Procedure
|
N/A | |
Completed |
NCT04360369 -
Comparison of Intraocular Pressure Measurements Between Reichert Tono-Vera Tonometer and Goldmann Tonometry
|
N/A | |
Completed |
NCT04521140 -
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery
|
Phase 4 | |
Completed |
NCT05167773 -
Clinical Study of the Topcon Tonometer TRK-3
|