Intraocular Pressure Clinical Trial
Official title:
Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects
NCT number | NCT00712400 |
Other study ID # | OPHT-070703 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 2005 |
Est. completion date | January 2010 |
Verified date | June 2018 |
Source | Medical University of Vienna |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Latanoprost is a synthetic prodrug of 17-phenyl-substituted prostaglandin F2α analog. Used at
a dose of one drop per day, it has been reported to produce a 30 to 35% reduction in
intraocular pressure. Its mechanism of activation involves augmentation of the eye's natural
uveoscleral outflow capacity .
There is evidence that ocular blood flow plays a role in the clinical course of glaucoma.
Glaucoma medication that lowers IOP simultaneously increases ocular blood perfusion pressure,
which in turn may increase ocular blood flow.
This could well contribute to the partially contradicting results concerning ocular
hemodynamic effects of latanoprost. In vitro studies indicate that latanoprost has no effect
on ocular vascular tone in therapeutical doses. By contrast, it has been reported in several
studies that latanoprost 0.005% increases pulsatile ocular blood flow in patients with
primary open angle glaucoma and normal tension glaucoma. This increase in pulsatile ocular
blood flow mainly reflects an increase in the choroidal circulation.
Little is known about the potential effect of latanoprost on choroidal blood flow regulation
in humans. The present study therefore tries to elucidate whether treatment with latanoprost
may alter choroidal blood flow regulation during artificial changes in ocular perfusion
pressure. In addition, the present study aims to clarify whether the change in choroidal
blood flow after latanoprost administration are due to direct vasoactive effects or due to
the increase in ocular perfusion pressure. The second alternative may have important
implications on our understanding of glaucoma treatment, because reduction of IOP may then
per se result in normalization of ocular blood flow regulation.
Status | Completed |
Enrollment | 24 |
Est. completion date | January 2010 |
Est. primary completion date | September 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 19 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Men aged between 19 and 35 years, nonsmokers - Body mass index between 15th and 85th percentile (Must et al. 1991) - Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant - Normal ophthalmic findings, ametropia < 3 dpt. Exclusion Criteria: - Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study - Treatment in the previous 3 weeks with any drug - Symptoms of a clinically relevant illness in the 3 weeks before the first study day - History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of study drugs - Blood donation during the previous 3 weeks - Ametropia >= 3 dpt - Iris bicolor |
Country | Name | City | State |
---|---|---|---|
Austria | Department of Clinical Pharmacology | Vienna |
Lead Sponsor | Collaborator |
---|---|
Medical University of Vienna |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Choroidal pressure-flow relationship | in total 4 hours |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03494257 -
Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification
|
N/A | |
Completed |
NCT03016234 -
IOP Changes With Different Anesthetic Agents During Laparoscopic Colorectal Surgery
|
N/A | |
Completed |
NCT04863209 -
Effect of Osteopathic Techiniques on Intraocular Pressure
|
N/A | |
Completed |
NCT02646033 -
Quantitative Rise in Intraocular Pressure in Steep Trendelenburg Position
|
||
Completed |
NCT03139708 -
The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients
|
Phase 1 | |
Recruiting |
NCT02697825 -
Intraocular Pressure Versus Optic Nerve Sheath Diameter
|
N/A | |
Completed |
NCT02985567 -
An Observational Study of the Use of Chloral Hydrate for Ophthalmic Procedures in Children
|
N/A | |
Withdrawn |
NCT00837226 -
Effects of Weight Loss From Bariatric Surgery on Intraocular Pressure (IOP)
|
N/A | |
Completed |
NCT02136589 -
Effect of NSAID on Travoprost-induced Conjunctival Hyperemia and IOP Reduction in Normal Eyes
|
Phase 4 | |
Completed |
NCT03123614 -
Loteprednol vs. Prednisolone and Fluorometholone
|
Phase 4 | |
Completed |
NCT05763056 -
Effects of Intubation on Intra-ocular Pressure and Optic Nerve Sheath Diameter
|
N/A | |
Completed |
NCT03359200 -
Analysis of the Microbiota in Goldmann Applanation Tonometers at a Reference Service in Goiânia
|
N/A | |
Completed |
NCT02816905 -
Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery
|
Phase 4 | |
Withdrawn |
NCT02558309 -
Optic Nerve Head Quantification While Reducing Elevated Intracranial Pressure
|
N/A | |
Completed |
NCT01786954 -
iCare vs Tonopen vs Goldmann Applanation Post-vitrectomy Surgery
|
N/A | |
Completed |
NCT00552019 -
Intraocular Pressure (IOP) Assessed by Dynamic Contour Tonometer (DCT) and Goldman Applanation Tonometry (GAT)
|
N/A | |
Completed |
NCT00428740 -
Long-Term IOP Fluctuation and VF Progression After Triple Procedure
|
N/A | |
Completed |
NCT04360369 -
Comparison of Intraocular Pressure Measurements Between Reichert Tono-Vera Tonometer and Goldmann Tonometry
|
N/A | |
Completed |
NCT04521140 -
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery
|
Phase 4 | |
Completed |
NCT05167773 -
Clinical Study of the Topcon Tonometer TRK-3
|