Intraocular Melanoma Clinical Trial
Official title:
A Phase 2 Study Of Weekly Infusion Nab-paclitaxel (Paclitaxel Protein-bound Particles for Injectable Suspension) In Patients With Unresectable And Metastatic Uveal Melanoma
RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle
formulation, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing.
PURPOSE: This phase II trial is studying how well paclitaxel albumin-stabilized nanoparticle
formulation works in treating patients with metastatic melanoma of the eye that cannot be
removed by surgery.
OBJECTIVES:
Primary
- To evaluate the overall response rate of patients with unresectable, metastatic uveal
melanoma treated with paclitaxel albumin-stabilized nanoparticle formulation.
Secondary
- To determine the median progression-free survival of patients treated with this
regimen.
- To determine the overall survival of patients treated with this regimen.
OUTLINE: Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30
minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease
progression or unacceptable toxicity.
After completion of study therapy, patients are followed every 8 weeks for 1 year.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT01217398 -
Temozolomide and Bevacizumab in Treating Patients With Metastatic Melanoma of the Eye
|
Phase 2 | |
Completed |
NCT00471471 -
Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
|
Phase 1 | |
Completed |
NCT00398073 -
Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma
|
N/A | |
Completed |
NCT00334776 -
Vaccine Therapy in Treating Patients With Metastatic Melanoma
|
Phase 2 | |
Completed |
NCT00025181 -
Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery
|
Phase 1 | |
Terminated |
NCT00002947 -
Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
|
Phase 1 | |
Completed |
NCT00897624 -
Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma
|
N/A | |
Completed |
NCT00003339 -
Vaccine Therapy With or Without Interleukin-12 in Treating Patients With Stage III or Stage IV Melanoma
|
Phase 2 | |
Completed |
NCT00084656 -
Monoclonal Antibody Therapy and Vaccine Therapy in Treating Patients With Resected Stage III or Stage IV Melanoma
|
Phase 2 | |
Completed |
NCT00705640 -
Vaccine Therapy in Treating Patients With Advanced Melanoma
|
Phase 1 | |
Recruiting |
NCT00489944 -
Sunitinib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Ocular Melanoma
|
Phase 2 | |
Completed |
NCT00027742 -
Temozolomide and Interferon Alfa in Treating Patients With Stage III or Stage IV Melanoma
|
Phase 2 | |
Completed |
NCT00952939 -
Study of Tumor Samples in Patients Undergoing Radiation Therapy or Surgery For Primary Melanoma of the Eye
|
N/A | |
Terminated |
NCT00005841 -
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma
|
Phase 1 | |
Completed |
NCT00072345 -
Temozolomide, Thalidomide, and Lomustine in Treating Patients With Unresectable Stage III or Stage IV Melanoma
|
Phase 2 | |
Completed |
NCT00089219 -
Vaccine Therapy in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Melanoma
|
Phase 1/Phase 2 | |
Completed |
NCT00445965 -
Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer
|
Phase 2 | |
Completed |
NCT00243061 -
AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma
|
Phase 2 | |
Terminated |
NCT00110123 -
Intravenous or Hepatic Arterial Infusion of Fotemustine in Treating Patients With Unresectable Liver Metastases From Eye Melanoma
|
Phase 3 | |
Completed |
NCT00032045 -
Vaccine Therapy and Monoclonal Antibody Therapy in Treating Patients With Stage IV Melanoma
|
Phase 2 |