Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation

Intractable Epilepsy Clinical Trial

— DTI/SEP  

Official title:

Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02846272
• Other study ID #: HSC-MS-15-0022
• Status: Recruiting
• Phase: N/A
• Start date: November 2015
• Est. completion date: January 1, 2031

Study information

• Verified date: May 2022
• Source: The University of Texas Health Science Center, Houston
• Contact: Manish N Shah, M.D.
• Phone: 713 500-7410
• Email: Manish.N.Shah[@]uth.tmc.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.

Description:

To determine if diffusion tensor and functional connectivity magnetic resonance imaging helpful to better understand and diagnose intractable epilepsy in children. All enrolled children will undergo standard preoperative and postoperative MRI imaging, plus a 15 minute set of functional connectivity and diffusion tensor sequence with no additional sedation. This imaging data will be stripped of identifiers and be processed to provide both quantitative analysis, resting state functional connectivity changes and three dimensional modeling of white matter tracts adjacent to epileptogenic foci. This study is being done to determine if diffusion tensor and functional connectivity magnetic resonance imaging are helpful to better understand and diagnose intractable epilepsy in children.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: January 1, 2031
• Est. primary completion date: January 1, 2030
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• Children diagnosis with Intractable Epilepsy

Exclusion Criteria:

• No Intractable Epilepsy

Related Conditions & MeSH terms

• Drug Resistant Epilepsy
• Epilepsy
• Intractable Epilepsy

Intervention

Procedure:
• Observation
Observation of MRI changes in subjects

Locations

Country	Name	City	State
United States	UTHealth & Children's Memorial Hermann Hospital	Houston	Texas

Sponsors (1)

Lead Sponsor	Collaborator
The University of Texas Health Science Center, Houston

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants with seizure outcome as determined by Engel		5 years