Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.


Clinical Trial Description

The hypothesis is that a neurologic exam performed when the subject has continuous infusion of precedex will result in less brain injury (where the lactate/pyruvate ratio indicates injury) then when a neurologic exam is performed on subjects receiving propofol, because that exam requires that the propofol infusion be stopped. ;


Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00538616
Study type Interventional
Source Duke University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date January 2008
Completion date April 2010

See also
  Status Clinical Trial Phase
Completed NCT02710123 - Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion N/A
Recruiting NCT02777060 - Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures N/A
Completed NCT02262286 - MIND (Management of Traumatic Brain Injury Diagnosis) N/A
Completed NCT01461902 - Vasospasm in Pediatric Traumatic Brain Injury N/A
Recruiting NCT01198964 - Optimization of Human Cortical Stimulation
Active, not recruiting NCT01207050 - Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Phase 4
Completed NCT00875329 - Traumatic Brain Injury (TBI) Screening Instruments N/A
Completed NCT01201863 - Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Phase 4
Completed NCT01059890 - Cerebral Antibiotics Distribution After Acute Brain Injury Phase 1
Completed NCT01035606 - Training in Goal-directed Attention Regulation for Individuals With Brain Injury N/A
Completed NCT00571623 - Automated Chest Physiotherapy to Improve Outcomes in Neuro N/A
Completed NCT00596765 - Neuropsychological Cognitive Behavioral Therapy for Patients With Acquired Brain Injury N/A
Completed NCT00336466 - The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS) Phase 2
Recruiting NCT05105763 - Biofeedback Gait Retraining for Stiff Knee Gait Correction N/A
Recruiting NCT02495558 - Cough Assessment in Patients With Severe Acquired Brain Injury N/A
Completed NCT02100592 - Early Verticalization in neuroICU With ERIGO: a Safety and Feasibility Study Phase 1/Phase 2
Completed NCT00797680 - Duration of Hypothermia for Neuroprotection After Pediatric Cardiac Arrest Phase 2
Completed NCT00018499 - Genotype Influence on Recovery After Traumatic Brain Injury N/A
Recruiting NCT02567201 - Electrophysiological Evaluation of Voluntary Attention N/A
Withdrawn NCT05581927 - Whole-Body Hypothermia for Neonates With Hypoxic-Ischemic Encephalopathy(HIE) N/A