Tractography Pilot Study Leipzig

Status Completed

Clinical Trial Summary

In this pilot study participants will undergo routine magnetic resonance imaging and routine neurosurgical care. By prospectively collecting data from both MRI and patient records we want to investigate biomarkers derived from tractography and diffusion tensor imaging to predict rehabilitation potential.

Clinical Trial Description

Patients will undergo MRI before and after surgery with DTI. With CSD-tractography, fiber bundles and their volumes will be identified. By measuring fractional anisotropy (FA) within these volumes, a correlation with clinical outcome and recovery will be tested. Also, FA frequency distributions will be used to describe white matter integrity and to thereby improve future tractography algorithms. Fiber bundles of interest will be the arcuate fascicle (AF), the corticospinal tract (CST), frontal aslant tract (FAT), the inferior fronto-occipital fascicle (IFOF), the inferior longitudinal fascicle (ILF) and the uncinate fascicle (UF). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04302857
Study type	Observational
Source	University of Leipzig
Contact
Status	Completed
Phase
Start date	January 1, 2020
Completion date	December 31, 2021

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