Intracranial Germ Cell Tumor Clinical Trial
Official title:
Evaluating Changes of Brain Networks and White Matter Fibers by fMRI and DTI After Treatments in Patients With Germ Cell Tumors in the Basal Ganglia
BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.
Primary intracranial germ cell tumors are a specific entity of brain tumors with a variety of
histological types and different degrees of malignancy. Intracranial GCTs make up 11.2% -
15.3% of primary intracranial tumors in Asian children compared with 3.6% in the US. And
tumors located at the basal ganglia is much rarer.
The investigators realize that most of patients with tumors at this location are involved
with motor disfunction. And after treatments, some patients get relieved dramatically, but
some others failed to get similar outcomes. To better understand the mechanism causing this
difference of treatment outcomes, the investigators perform BOLD-fMRI and DTI scans to
patients with germ cell tumors in the basal ganglia before and after treatments. The changes
of the fMRI and muscle strength of patients during treatments are evaluated, and the
association between these two are investigated.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04909307 -
Surveillance of Association of Immune Status and Prognosis of CNS Germ Cell Tumor Survivors
|