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Intracranial Germ Cell Tumor clinical trials

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NCT ID: NCT04909307 Recruiting - Surgery Clinical Trials

Surveillance of Association of Immune Status and Prognosis of CNS Germ Cell Tumor Survivors

Start date: June 1, 2019
Phase:
Study type: Observational [Patient Registry]

Platinum-based chemotherapy, alternating at 21-days intervals with cycles of ifosfamide, cisplatin, and etoposide (ICE) and subsequently received radiotherapy were considered as standard treatment for intracranial germ cell tumors. However, whether reliable clinical data can quantify the damage degree of immunologic function caused by chemotherapy and radiotherapy is still unknown. This project regards the level of lymphocyte and immunocyte in peripheral blood as a quantitative index to reflect the dynamic change of the immunologic function of patients with CNS germ cell tumors before and after chemoradiotherapy treatment. Meanwhile, the investigators will also investigate the relationship between the level of lymphocyte and immunocyte in peripheral blood and the response rate of therapy.This study is designed to prospectively analyze the dynamic changes of immune status, prognosis and society function after standard treatment in patients with intracranial germ cell tumor.

NCT ID: NCT03771625 Recruiting - Clinical trials for Intracranial Germ Cell Tumor

Evaluating Structural and Functional Changes of Brain by fMRI and DTI in Patients With Intracranial Germ Cell Tumors

Start date: June 1, 2019
Phase:
Study type: Observational [Patient Registry]

BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.