Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)

Intracerebral Hemorrhage Clinical Trial

— ERICH  

Official title:

Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01202864
• Other study ID #: 1008059
• Secondary ID: R01NS069763-01
• Status: Completed
• Phase: N/A
• First received: September 14, 2010
• Last updated: August 31, 2017
• Start date: August 1, 2010
• Est. completion date: August 1, 2017

Study information

• Verified date: August 2017
• Source: University of Cincinnati
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to find risk factors for hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), among Caucasians, African Americans, and Hispanics.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6000
• Est. completion date: August 1, 2017
• Est. primary completion date: July 31, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

All cases must meet the following eligibility criteria:

1. Age 18 years or greater, fulfillment of the criteria for intracerebral hemorrhage

2. Resident for at least 6 months within 50 miles of the recruiting center

3. No evidence of trauma, vascular malformation or aneurysm, or brain tumor as a cause of the hemorrhage

4. Ability of the patient or legal representative to provide informed consent

Exclusion Criteria:

Exclusion Criteria:

1. Malignancies leading to coagulopathy

2. Hemorrhagic transformation of ischemic infarct

3. Hemorrhage secondary to dural venous sinus thrombosis

Related Conditions & MeSH terms

• Cerebral Hemorrhage
• Hemorrhage
• Intracerebral Hemorrhage

Locations

Country	Name	City	State
United States	University of New Mexico	Albuquerque	New Mexico
United States	Emory University	Atlanta	Georgia
United States	University of Maryland	Baltimore	Maryland
United States	Massachusetts General Hospital	Boston	Massachusetts
United States	University of Illinois	Chicago	Illinois
United States	University of Texas Southwestern Medical Center at Dallas	Dallas	Texas
United States	University of Texas Medical School at Houston	Houston	Texas
United States	University of Southern California	Los Angeles	California
United States	University of Miami	Miami	Florida
United States	University of Miami - Biorepository	Miami	Florida
United States	Columbia University	New York	New York
United States	University of Texas Health Science Center at San Antonio	San Antonio	Texas
United States	University of Arizona	Tucson	Arizona
United States	Georgetown University	Washington, D.C.	District of Columbia
United States	Wake Forest University	Winston-Salem	North Carolina

Sponsors (20)

Lead Sponsor

Collaborator

University of Cincinnati

Columbia University, Duke University, Emory University, Georgetown University, Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS), St. Luke's-Roosevelt Hospital Center, The University of Texas Health Science Center at San Antonio, The University of Texas Health Science Center, Houston, University of Arizona, University of California, San Francisco, University of Illinois at Chicago, University of Maryland, University of Miami, University of New Mexico, University of Southern California, University of Texas, Southwestern Medical Center at Dallas, University of Virginia, Wake Forest University

Country where clinical trial is conducted

United States, 

References & Publications (16)

Barber M, Stott DJ. Validity of the Telephone Interview for Cognitive Status (TICS) in post-stroke subjects. Int J Geriatr Psychiatry. 2004 Jan;19(1):75-9. — View Citation

Broderick JP, Brott T, Tomsick T, Miller R, Huster G. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg. 1993 Feb;78(2):188-91. — View Citation

Broderick JP, Phillips SJ, Whisnant JP, O'Fallon WM, Bergstralh EJ. Incidence rates of stroke in the eighties: the end of the decline in stroke? Stroke. 1989 May;20(5):577-82. — View Citation

Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997 Jan;28(1):1-5. — View Citation

Davis SM, Broderick J, Hennerici M, Brun NC, Diringer MN, Mayer SA, Begtrup K, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology. 2006 Apr 25;66(8):1175-81. — View Citation

de Jager CA, Budge MM, Clarke R. Utility of TICS-M for the assessment of cognitive function in older adults. Int J Geriatr Psychiatry. 2003 Apr;18(4):318-24. — View Citation

Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology. 2004 Sep 28;63(6):1059-64. — View Citation

Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev MH, Rosand J. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology. 2007 Mar 20;68(12):889-94. — View Citation

Hardie K, Hankey GJ, Jamrozik K, Broadhurst RJ, Anderson C. Ten-year survival after first-ever stroke in the perth community stroke study. Stroke. 2003 Aug;34(8):1842-6. Epub 2003 Jul 3. — View Citation

Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, Woo D, Szaflarski J, Gebel J, Moomaw C, Pancioli A, Jauch E, Shukla R, Broderick J. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004 Feb;35(2):426-31. — View Citation

Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, Rosand J. Anemia and hematoma volume in acute intracerebral hemorrhage. Crit Care Med. 2009 Apr;37(4):1442-7. doi: 10.1097/CCM.0b013e31819ced3a. — View Citation

MAHONEY FI, BARTHEL DW. FUNCTIONAL EVALUATION: THE BARTHEL INDEX. Md State Med J. 1965 Feb;14:61-5. — View Citation

Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; FAST Trial Investigators. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008 May 15;358(20):2127-37. doi: 10.1056/NEJMoa0707534. — View Citation

RANKIN J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J. 1957 May;2(5):200-15. — View Citation

Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW, Jacobson MF. Lifetime cost of stroke in the United States. Stroke. 1996 Sep;27(9):1459-66. Review. — View Citation

Woo D, Sauerbeck LR, Kissela BM, Khoury JC, Szaflarski JP, Gebel J, Shukla R, Pancioli AM, Jauch EC, Menon AG, Deka R, Carrozzella JA, Moomaw CJ, Fontaine RN, Broderick JP. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. 2002 May;33(5):1190-5. — View Citation

* Note: There are 16 references in all — Click here to view all references