Intracerebral Hemorrhage Clinical Trial
Official title:
Introduction of Protein S100 in the Routine Diagnostics in Patients With Minor Head Injury
In Patients with minor head injury measurement of protein S100 will be introduced to the emergency departement as another tool to rule out intracerebral bleeding.
Severe intracerebral bleeding is still a complication even in obvious minor head injury
(MHI) that makes the use of CT scanning necessary in patients with only few signs of
intracerebral injury. To reduce the number of cerebral CT scans without pathologic findings
measurement of protein S100 level in serum will be used in the emergency departement (ED) at
our hospital.
Our hypothesis: with measurement of S100 levels cCT scans and inpatient treatment can be
reduced, radiation and costs can be reduced.
From January 1st 2010 for 3-6 months all patients with head injury (all GCS) will be tested
for their initial S100 level. Cut off level is set at 0,105ng/ml. During this period test
results will be blinded. Decisions for further diagnostics (x-ray, cCT) and inpatient vs.
outpatient treatment are made on clinical impressions as they are made now. The test results
will be monitored and compared with clinical cases. Sensitivity, specificity, positive and
negative predictive values will be measured.
The aim is to identify patients without risk for intracerebral bleeding (ie S100 level lower
than 0,105ng/ml). Those can be managed in an outpatient way. All other patients will be
diagnosed and treated as it is now.
If the test will not miss one intracranial bleeding and will save cCT scans and inpatient
treatment, measurement of protein S100 will become a routine diagnostic in our ED for
patients with MHI.
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Observational Model: Case-Only, Time Perspective: Prospective
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