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Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects

Intrabony Periodontal Defect Clinical Trial

Official title:
Comparative Efficacy of Titanium Granules Over Hydroxyapatite in the Treatment of Periodontal Intrabony Defects: A Clinico-radiographic Study

Clinical Trial Summary

The ideal goal of the periodontal treatment is not only to prevent the progression of the disease, but also the regeneration and reconstruction of lost tissues. Many surgical techniques have been used to regenerate intrabony defects (IBD). Titanium stimulates activation of the complement system, surface binding of platelets, and platelet activation as reflected by increased levels of platelet-derived growth factor, which is a substantial promoter of bone growth. Hence we may speculate that using a bone substitute made of titanium may be positive from the perspective of bone formation in osseous defects.

Clinical Trial Description

Titanium granules consist of irregular porous granules of commercially pure titanium. The porous properties may lead to ingrowth of newly formed bone.The osseointegrating response to titanium may be the result of the potent activation of the intrinsic coagulation system and the subsequent release of growth factors from platelets.Therefore, the aim of this study is to compare the effect of titanium particles and hydroxyapatite on osseous regeneration in intrabony defects. After reflection of flap and degranulation, bone graft i.e., titanium particles (test group) or hydroxyapatite(control group) will be placed in the void created by the defect and sutures will be placed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04932161
Study type Interventional
Source SVS Institute of Dental Sciences
Contact R V Chandra, MDS;DNB;PhD
Phone 9908183071
Email viswachandra@hotmail.com
Status Recruiting
Phase N/A
Start date August 2021
Completion date December 2022
View Details
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