Intrabony Periodontal Defect Clinical Trial
Official title:
"Comparative Evaluation Of The Efficacy Of Atorvastatin Gel As An Adjunct To Allografts In The Treatment Of Intrabony Defects" - A Clinico Radiological Study
Periodontitis is a major oral health problem which leads to the progressive destruction of
periodontal ligament and alveolar bone with pocket formation, recession or both. The
ultimate goal of periodontal therapy is to regenerate the lost periodontal tissue. The most
common form of regenerative periodontal therapy is the use of bone grafts which stimulate
bone formation by the processes of osteoinduction and osteoconduction.
Statins are a group of lipid lowering drugs which inhibit bone resorption by inhibition of
the enzyme HMG-CoA reductase. They also stimulate new bone formation by local stimulation of
BMP-2, a major bone growth regulatory factor. They also have anti-inflammatory and anti
oxidant properties.
Very few studies exist evaluating the beneficiary effects of grafts if combined with the
statins which might enhance the regeneration by bone grafts.
Hence, the present study was carried out in an attempt to comparatively evaluate clinically
and radiologically, the efficacy of atorvastatin gel as an adjunct to allograft in the
treatment of intrabony defects.
A total of 26 intrabony defects in patients with chronic periodontitis as diagnosed by
radiographs, were selected for the study after taking an informed consent. The selected
sites were randomized in 2 treatment groups.
Group I - sites were treated with allograft (DFDBA) Group II - sites were treated with
allograft (DFDBA) in combination with Atorvastatin gel.
Clinical parameters like probing depth and clinical attachment level and radiological
assessment of intrabony defect fill were done at baseline and 3 and 6 months
postoperatively.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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