Intrabony Periodontal Defect Clinical Trial
Official title:
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects: A Randomized, Controlled Clinical Trial.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
Status | Completed |
Enrollment | 32 |
Est. completion date | April 2016 |
Est. primary completion date | April 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 30 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Systemically healthy patients having an intra-osseous defect with probing depth = 7mm at baseline, presence of a = 4mm vertical inter-proximal bone defect with at least one bony wall after surgical debridement and with no history of previous periodontal therapy were included into the study Exclusion Criteria: - Patients with known systemic diseases, aggressive periodontitis, smoking habit, known or suspected allergy to bisphosphonates, pregnant and lactating women, study tooth exhibiting tooth mobility greater than grade II and class III furcation defect were excluded from the study. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre |
Gupta J, Gill AS, Sikri P. Evaluation of the relative efficacy of an alloplast used alone and in conjunction with an osteoclast inhibitor in the treatment of human periodontal infrabony defects: a clinical and radiological study. Indian J Dent Res. 2011 M — View Citation
Sharma A, Pradeep AR. Clinical efficacy of 1% alendronate gel as a local drug delivery system in the treatment of chronic periodontitis: a randomized, controlled clinical trial. J Periodontol. 2012 Jan;83(1):11-8. doi: 10.1902/jop.2011.110091. Epub 2011 M — View Citation
Veena HR, Prasad D. Evaluation of an aminobisphosphonate (alendronate) in the management of periodontal osseous defects. J Indian Soc Periodontol. 2010 Jan;14(1):40-5. doi: 10.4103/0972-124X.65438. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Linear bone growth | Linear bone growth (LBG) was calculated as the difference between the cemento-enamel junction(CEJ) to base of defect (BD) distance at baseline and CEJ to BD distance at 6 months in radiographs. | change from baseline and 6 months | No |
Secondary | clinical attachment level (CAL) | distance between the cemento-enamel junction and base of the pocket | change from baseline and 6 months | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04319770 -
Effectiveness of Hyaluronic Acid in the Regeneration of Infrabony Defects
|
N/A | |
Completed |
NCT03651908 -
Comparison Between Bioactive Silica Graft Plus Platelet Rich Fibrin and Only Platelet Rich Fibrin Graft in Intrabony Defects With Diabetes
|
N/A | |
Enrolling by invitation |
NCT04971174 -
Outcomes of Periodontal Regenerative Treatment
|
||
Active, not recruiting |
NCT03922503 -
Clinical Effect of APRF With DFDBA Compare to Collagen Membrane With DFDBA in Intraosseous Defect
|
N/A | |
Completed |
NCT03924336 -
The Effect of A-PRF+ Versus Open Flap Debridement in the Treatment of Patients With Stage III Periodontitis
|
N/A | |
Not yet recruiting |
NCT05499598 -
Evaluation of Modified Minimally Invasive Surgical Technique and Platelet Rich Fibrin With or Without Vitamin Pool A and C for Management of Periodontal Intrabony Defects
|
N/A | |
Not yet recruiting |
NCT04444063 -
Clinical and Radiograhic Evaluation of NIPSA With and Without Allograft Plus Platelet Rich Fibrin in the Treatment of Intraosseous Defects in Stage III Periodontitis Patients
|
N/A | |
Completed |
NCT04896450 -
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
|
N/A | |
Completed |
NCT02828423 -
Regenerative Combined Therapy With Enamel Matrix Derivative and Biphasic Calcium Phosphate Graft
|
Phase 4 | |
Active, not recruiting |
NCT03900013 -
Injectable Platelet Rich Fibrin With Demineralized Freeze-dried Bone Allograft in Treatment of Intraosseous Defects
|
N/A | |
Completed |
NCT05456555 -
The Flapless Approach in Periodontal Regeneration
|
N/A | |
Not yet recruiting |
NCT03588507 -
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
|
N/A | |
Completed |
NCT02761668 -
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
|
N/A | |
Not yet recruiting |
NCT05569473 -
Evaluation of Volume Stable Collagen Matrix in the Regenerative Outcome of Periodontal Intrabony Defects
|
N/A | |
Completed |
NCT06041854 -
Allograft With Enamel Matrix Derivative Versus Allograft Alone in the Treatment of Intrabony Defects .
|
N/A | |
Completed |
NCT06371027 -
Novel Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgery in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial
|
N/A | |
Not yet recruiting |
NCT05858411 -
Efficacy of rhPDGF as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
|
N/A | |
Recruiting |
NCT06426524 -
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
|
N/A | |
Recruiting |
NCT05354037 -
Flapless Approach for the Treatment of Intrabony Defects
|
N/A | |
Recruiting |
NCT06048042 -
Evaluation of Autogenous Demineralized Dentin Graft Vs Autogenous Bone Graft in Management of Intrabony Defects
|
Phase 4 |