Intervertebral Disk Displacement Clinical Trial
Official title:
Analgetic and Anxiolytic Effect of Preoperative Pregabalin in Patients Undergoing Surgery of the Vertebral Columna
The purpose of this study is to determine whether the use of oral pregabalin 150 mg as
premedication reduces the amount and degree of postoperative pain.
Furthermore the purpose of this study is to determine whether the use of oral pregabalin 150
mg as premedication reduces anxiety prior to anaesthesia in these patients.
The mechanism of development of postoperative pain is complex. Central and peripheral
sensitization are playing an important role and this can lead to postoperative
hypersensitization. Several studies have shown, that gabapentin can be effective to reduce
sensitization and postoperative pain. Pregabalin (S-aminomethyl-5-methylhexaninacid) is a
further development of gabapentin. Pregabalin has a fewer side-effects compared with
gabapentin.
The purpose of this study is to compare the analgetic and anxiolytic effect of pregabalin
and placebo used as premedication.
The hypothesis is that a single-dose pregabalin (150 mg postoperatively (p.o.)) gives
significant better anxiolysis and analgesia than placebo.
The study is including patients undergoing surgery of the vertebral columna.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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