Genotype-related Molecular Targets in the Vitamin D Pathway for Spinal Disc Diseases — GenVDisc

Intervertebral Disk Degeneration Clinical Trial

Official title:
Identification of Genotype-related Molecular Targets in the Vitamin D Pathway for Personalized Pharmacological Treatments of the Spinal Disc Diseases

Status Recruiting

Clinical Trial Summary

The objective of our study will be to analyze the interplay between particular VDR variants and its ligand in cells obtained from intervertebral disc and cartilage endplate and their action on cell proliferation and phenotype maintenance. The identification of novel molecular targets in the vitamin D pathway, potentially promoting pathological alterations of the tissues involved in spinal disc diseases, will allow to develop innovative and more personalized preventive and pharmacological/nutritional therapies.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03343899
Study type	Observational
Source	Istituto Ortopedico Galeazzi
Contact
Status	Recruiting
Phase	N/A
Start date	February 17, 2016
Completion date	February 17, 2019

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