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Intervertebral Disc Displacement clinical trials

View clinical trials related to Intervertebral Disc Displacement.

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NCT ID: NCT01811251 Completed - Clinical trials for Patients Undergoing a Lumbar Slipped Disc Surgery

Co-analgesic Effects of Dexamethasone and Pregabalin After Lumbar Slipped Disc Surgery

DEXA-PG-HD
Start date: December 2012
Phase: Phase 3
Study type: Interventional

The aim of the study is to show a decrease in postoperative pain during the first postoperative mobilization surgery lumbar disc herniation through a co-analgesia with a single dose of dexamethasone, pregabalin, or a combination of these two products. Pain assessed by simple numerical scale will be also evaluated during the 48 first post-operative hours. Determining an optimal co-analgesic protocol through the results of this study could help develop validation studies with larger scale such as a medico-economic component. In addition, these study protocols are easy to apply (ponctual administration) and inexpensive.

NCT ID: NCT01694134 Completed - Low Back Pain Clinical Trials

Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies.

MODISC
Start date: July 12, 2012
Phase: Phase 3
Study type: Interventional

The treatment of chronic low back pain is a major objective of public healthcare, because it causes an important number of sick leaves. A correlation between clinical observations and an inflammatory discopathy has been underlined, but there is currently any reference treatment. In this study, the main objective is to assess the efficacy of an intradiscal injection of corticoids versus local anaesthetic on the treatment of pain of patients with low back pain associated to a Modic I discopathy.

NCT ID: NCT01662219 Completed - Clinical trials for Cervical Disc Prolapse

Effect of Superficial Cervical Plexus Block on the Postoperative Quality of Recovery

QoR
Start date: August 2012
Phase: N/A
Study type: Interventional

Pain and discomfort after anterior cervical spine surgery is difficult to quantify and quoted as moderate in severity, often needing oral opioid analgesics. In addition, these patients are more prone for postoperative respiratory complication due to airway edema secondary to surgical retraction or wound hematoma. Opioid analgesics provide good pain control but postoperative nausea and vomiting and respiratory depression are undesirable in these patients who are at risk for postoperative wound hematoma and airway edema The use of multimodal analgesia is rapidly becoming the 'standard of care' for preventing pain after ambulatory procedures at most surgery centers throughout the world . The purpose of this study is to determine whether superficial cervical plexus block will improve the postoperative quality of recovery as measured by Quality of Recovery 40 questionnaire (QoR-40) in patients undergoing elective anterior cervical discectomy and fusion.

NCT ID: NCT01640457 Completed - Clinical trials for Intervertebral Disc Degeneration

Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine

NDisc
Start date: August 2012
Phase: Phase 1/Phase 2
Study type: Interventional

NOVOCART® Disc plus is being investigated to explore its clinical applicability, safety and efficacy in the repair of a herniated disc with an indication for an elective sequestrectomy, and of the adjacent degenerated disc, if present. The objective of this clinical study is to provide basis for a confirmatory study design (endpoints, methodologies) (Phase II), and to develop a safety profile (Phase I). This study further aims at developing and validating known and new biologic markers for the quality and clinical efficacy of the product as requested in the context of identity, purity and potency characteristics of the medicinal/investigational product.

NCT ID: NCT01615328 Completed - Clinical trials for Intervertebral Disk Displacement

Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™

Start date: November 2011
Phase: Phase 4
Study type: Interventional

Anterior cervical discectomy and fusion (ACDF) has shown good treatment results for a variety of cervical spine diseases such as herniated intervertebral disc (HIVD), cervical spondylotic radiculopathy (CSR) and cervical spondylotic myelopathy (CSM). ACDF using autogenous iliac bone graft is gold standard, however, it may lead to donor-site morbidities. Preventing these complications, some authors have tried to use alterative bone graft substitutes. Among these alternatives, Cervios ChronOs™ which is the polyetheretherketone (PEEK) cage with b-tricalcium phosphate (TCP) has become popular and shown good clinical results. However, b-TCP has only osteoconduction ability of three osteogenic properties. Recently, Bonion™ which is the PEEK cage filled with hydroxyapatite (HA) / demineralized bone matrix (DBM) is introduced. HA/DBM mixture has abilities of osteoconduction and osteoinduction, therefore this alternative is expected to show superior bone fusion capability to PEEK cage with b-TCP. However, there has been no comparison study between the PEEK cage with b-TCP and the PEEK cage with HA/DBM. The purpose of this study is to evaluate bone fusion rate between these cervical spine cages using postoperative computed tomography (CT)

NCT ID: NCT01518582 Completed - Clinical trials for Cervicobrachial Neuralgia

GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study

Start date: August 2012
Phase: N/A
Study type: Observational

This is a prospective clinical study to assess the performance of the prosthesis according to a composite success criterion. The clinical and functional results and the patient's quality of life up to 24 months of follow-up will also be recorded. Granvia-c is a device NOT FDA-approved and NOT under investigation in the USA.

NCT ID: NCT01513694 Completed - Clinical trials for Intervertebral Disc Disease

Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease

Start date: January 2010
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this trial is to test the effectiveness of the use of a new therapeutic strategy in treating patients with degenerative disc disease lumbar intervertebral fusion with instrumented posterolateral autologous mesenchymal stem cells and arranged in a calcium phosphate ceramic (Conduit TM).

NCT ID: NCT01491399 Completed - Clinical trials for Degenerative Cervical Disc Disease

INFUSE™ BONE GRAFT/CORNERSTONE-SR™ Allograft Ring/ATLANTIS™ Anterior Cervical Plate- Pilot Study

Start date: September 1999
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to assess the safety and effectiveness of the Investigational implant as compared to the Control implant in the treatment of patients with one level or two adjacent levels of cervical symptomatic degenerative disc disease.

NCT ID: NCT01476774 Completed - Clinical trials for Disease (or Disorder); Intervertebral Disc, With Myelopathy (Manifestation)

NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain

Start date: August 2009
Phase: Phase 3
Study type: Interventional

This is a multiple-dose, double-blind, double-dummy, active-control, parallel-group, multi-center, safety and efficacy study.

NCT ID: NCT01339377 Completed - Disk, Herniated Clinical Trials

Safety and Effectiveness Study of the AO-1000 Device to Treat Contained Herniated Discs

Start date: August 2011
Phase: Phase 1
Study type: Interventional

To evaluate the safety and effectiveness of the AO-1000 device to treat and relieve the pain of symptomatic subjects with contained herniated discs. This single-arm pilot study will be used as a go vs. no-go decision on performing a randomized-controlled trial. The study's primary effectiveness objective is to demonstrate that the patient's functionality (based on Oswestry Disability Index scores) has improved from baseline at one month. The study's primary safety objective is to demonstrate that serious device/procedure related adverse events and subsequent surgical interventions are no greater than those in a literature control of other percutaneous disc decompression procedures at discharge, 1 month, 6 months, and 12 months post-treatment. Secondary objectives are to demonstrate procedural success and improvement in the pain and function of the subjects at 1, 6, and 12 months using the VAS and ODI scales as well as tracking analgesic medication use. Pain and function scores for each follow-up time will be compared to the baseline scores.