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Intervention Effect of TP and AOB-w on Acrylamide Exposure in Chinese Adolescents

Intervention Clinical Trial

Official title:
Intervention Effect of Tea Polyphenols (TP) and Water-Soluble Antioxidant Of Bamboo Leaves (AOB-w) on Short- and Long-term Internal Exposure of Acrylamide in Chinese Adolescents

Clinical Trial Summary

A double-blind randomized controlled trial (RCT) was conducted in current human study. This study aims to investigate the intervention effect of AOB-w on the short-term exposure and toxicokinetics of acrylamide, a dietary hazardous substance generated during heat processing, in Chinese adolescents.

Clinical Trial Description

In the morning of test day, participants were served with a meal of potato chips, corresponding to a single oral dose of 12.6 μg/kg b.w. exposure to acrylamide, and an edible capsule, which contains 350 mg AOB-w or the placebo with the same dose. Urine were collected within 48 hours thereafter. The diet was rigorously controlled within 24 hours prior to study till entire study finished. Four mercapturic acid metabolites have been investigated as urinary biomarkers for short-term internal exposure of acrylamide in human ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03118167
Study type Interventional
Source Zhejiang University
Contact
Status Completed
Phase N/A
Start date May 2014
Completion date December 2014
View Details
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