Collagen-targeted PET Imaging for Early Interstitial Lung Disease

Status Recruiting

Clinical Trial Summary

The goal of this study is to investigate the ability of [68Ga]CBP8 to detect collagen deposition in early interstitial lung disease.

Clinical Trial Description

[68Ga]CBP8, is a PET imaging probe which selectively binds collagen type I. Collagen deposition is a pivotal event in the development of pulmonary fibrosis. [68Ga]CBP8 binds collagen with high affinity and has excellent pharmacological and pharmacokinetic profiles. [68Ga]CBP8 was shown in a mouse model to be effective for detecting lung fibrosis and response to treatment. In addition, [68Ga]CBP8 can detect increased collagen in the lungs of patients with idiopathic pulmonary fibrosis. The goals of this study are: 1. To determine whether collagen deposition as assessed by [68Ga]CBP8-PET MRI can detect increased collagen deposition in early interstitial lung disease and 2. if the degree of [68Ga]CBP8 uptake predicts subsequent disease progression. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05417776
Study type	Interventional
Source	Massachusetts General Hospital
Contact	Sydney B Montesi, MD
Phone	617-724-4030
Email	sbmontesi@partners.org
Status	Recruiting
Phase	Phase 2
Start date	September 28, 2022
Completion date	April 1, 2024

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