Intersticial Lung Disease Clinical Trial
Official title:
Can Nasal High-Flow Oxygen Therapy Improve Oxygenation During Exercise, Optimizing Benefits of Pulmonary Rehabilitation in Patients With Interstitial Lung Disease (ILD) With Exercise Desaturation?
Objectives: 1.- To compare the level of oxygenation achieved during muscular training with
conventional oxygen systems (nasal cannulas) versus nasal High-flow oxygen therapy. 2.-To
compare benefits achieved with both systems, in terms of: level of exercise during training;
effort tolerance in the 6 minutes walking test (6MWT); improvement of dyspnoea and
Health-related quality of life (HRQoL). And analyse the effects of nasal High-flow oxygen
therapy on the acute exercise in a subgroup of patients.
Method: Multicentric randomized clinical trial. Patients with ILD in fibrotic phase who
present oxygen desaturation during 6MWT (SpO2 mean ≤ 85%) will be included consecutively.
Will be randomized in two groups: ILD patients with conventional oxygen (EPIDOC) and ILD
patients with nasal High-Flow oxygen therapy (EPIDOAF). Both groups will perform a Pulmonary
Rehabilitation Program. Oxygen will be titrated respectively to flow and FiO2 needed to
maintain SpO2 ≥ 90% during training with both systems. Evaluation measures: SpO2 during
training in both groups; dyspnoea (mMRC scale and CRQ dyspnoea); exercise capacity (6MWT) and
HRQoL (self- administered KBILD questionnaire and SF36). In a subgroup of patients will be
compared time of endurance exercise to evaluate the effects of nasal high-flow oxygen therapy
in the acute exercise.
n/a