The Modulatory Effect of Oxytocin on Interoception

Interoception Clinical Trial

Official title:

The Modulatory Effect of Oxytocin on Interoception

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03074409
• Other study ID #: UESTC-neuSCAN-34
• Status: Completed
• Phase: N/A
• Start date: March 2, 2017
• Est. completion date: September 12, 2017

Study information

• Verified date: September 2019
• Source: University of Electronic Science and Technology of China
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is designed to investigate oxytocin's effects on interoception and whether these effects vary as a function of different emotional valence.

Description:

The present study will use a double-blind, between-subject, placebo-controlled design to investigate the modulatory effect of oxytocin on interoception and whether this effect will vary as a function of emotional valence. In Experiment 1, subjects will perform a heartbeat detection task and the group differences between oxytocin and placebo groups of the interoceptive accuracy and neural activity in the core interoceptive network will be investigated. In Experiment 2, subjects will be asked to watch emotional faces while perform the heartbeat detection task. Investigators will examine whether oxytocin's effects on interoception will be varied as a function of different emotional valence.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 83
• Est. completion date: September 12, 2017
• Est. primary completion date: September 6, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy subjects

Exclusion Criteria:

• Subjects reported having any neurological problems, psychiatric illness or drug or alcohol abuse and none were currently taking any form of medication and had not drunk any caffeine-containing beverages on the day of the experiment.

Related Conditions & MeSH terms

• Interoception

Intervention

Drug:
• oxytocin
self-administration of oxytocin (nasal spray)
• placebo
self-administration of placebo (nasal spray)

Locations

Country	Name	City	State
China	University of Electronic Science and Technology of China	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
University of Electronic Science and Technology of China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Heartbeat Detection (Interoception) Accuracy	heartbeat detection (interoception) accuracy is calculated by the following equation: 1/N ? (1 - (|recorded heartbeats - counted heartbeats|)/recorded heartbeats). N was the number of blocks for the heartbeat detection task.	45 minutes after oxytocin/placebo treatment
Primary	Interoceptive Network Activity	interoceptive network (including anterior insula and dorsal cingulate cortex) activity as measured by the functional MRI technique in the heartbeat detection task. In the heartbeat detection task participants were instructed to make a keypress each time they felt their heartbeat. The interoceptive network activity was indicated by the percentage of BOLD signal change. The value of the percentage of BOLD signal change indicates the level of a certain brain region activated (the involvement of a brain region in a specific cognitive process).	45 minutes after oxytocin/placebo treatment