The Behavioral and Brain Mechanism of IGD

Internet Gaming Disorder Clinical Trial

Official title:

The Behavioral and Brain Mechanism of Internet Gaming Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02550405
• Other study ID #: BeijingNormalU
• Status: Completed
• Phase: N/A
• Start date: March 2012
• Est. completion date: December 2015

Study information

• Verified date: December 2018
• Source: Beijing Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This project aims to investigate whether anodal tDCS of dlPFC enhances cognitive regulation over craving an emotions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 204
• Est. completion date: December 2015
• Est. primary completion date: December 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Inclusion criteria for IGDs were:

1. a score of 67 or higher on the CIAS;

2. engagement in Internet gaming for over 14 hours per week for a minimum of one year; and

3. reporting of Internet gaming as their primary online activity;

• Inclusion criteria for HCs were:

1. a score < 60 on the CIAS;

2. never having spent more than 2 hours per week engaged in Internet gaming

Exclusion Criteria:

• for all participants:

1. current or history of use of illegal substances and gambling;

2. current or history of psychiatric or neurological illness; and

3. current use of psychotropic medications

Related Conditions & MeSH terms

• Internet Gaming Disorder

Intervention

Behavioral:
• Craving behavioral intervention
The CBI was given once a week for 6 weeks, conducted by four therapists. A pair of therapists was randomly assigned to a CBI+ group. Each session included 5 parts in 2.5-3 hours: warming-up exercise, discussion about the homework from the last session, main structured activity, brief summary, and the homework assignment. There were 6 sessions with each focused on a topic: recognize craving and its relationship with IGD; reduce craving through ameliorating the salience of cues and irrational beliefs, withdrawal symptoms and other negative affects; enhance self-monitoring and control for craving through time management training; relieve ful?llment of psychological needs through Internet use and attenuate the relation between craving and gaming behaviors through coping skill training

Locations

Country	Name	City	State
China	State Key Laboratory of Cognitive Neuroscience and Learning	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Normal University

Country where clinical trial is conducted

China, 

References & Publications (1)

Dong G, Potenza MN. A cognitive-behavioral model of Internet gaming disorder: theoretical underpinnings and clinical implications. J Psychiatr Res. 2014 Nov;58:7-11. doi: 10.1016/j.jpsychires.2014.07.005. Epub 2014 Jul 17. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain resting state functional connectivity as measured by fMRI	voxel-wise, ROI-wise, and ICA analyses	Detecting changes between two different time points (baseline and 6 weeks)
Primary	Brain activation during a cue-induced craving task as measured by fMRI	A paradigm using addictive pictures to induce craving	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	Brain activation during the Cups task as measured by fMRI	Cups task measuring risky decision-making related to potential gains and losses separately	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	Brain activation during the mixed gambling task tasks as measured by fMRI	The mix gambling task measuring decision-making related to loss aversion	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	Brain structure as measured by structural MRI	comparing gray matter and white matter differences between individuals with IGD and healthy controls.	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	IGD severity measured by Chen Internet addiction scale	a 26-item 4-point Likert scale	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	Craving as measured by brief questionnaire of Internet (gaming) craving	a 8-item 7-point Likert scale	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	Impulsivity as measured by Barratt impulsive scale (BIS-II)	a 30-item 4-point Likert scale	Detecting changes between two different time points (baseline and 6 weeks)
Secondary	weekly online (gaming) time	self-report,in hours	Detecting changes between two different time points (baseline and 6 weeks)