Intermittent Claudication Clinical Trial
Official title:
Effet Des Gestes de Revascularisation à l'étage Proximal
The whole study is divided in 4 parallel protocols. The first protocol estimates the
reliability of the technique through test-retest recordings. The second protocol aims to
prove that exercise Tcpo2 is efficient to estimate the benefit of proximal revascularisation
on proximal and distal ischemia in patients suffering stage two lower extremity arterial
disease. The third protocol aims at estimating with exercise tcpo2 the eventual apparison of
proximal ischemia after aorto-bi-femoral bypasses. The last protocol is a transversal study
of patients with aorto-bi-femoral bypasses aiming to analyse the presence of proximal and
distal symptoms and ischemia.
The hypothesis for protocol 2 is that TcpO2 at exercise is significantly improved after
surgery at the aortic and primary iliac artery. The hypothesis for protocols 3 and 4 relates
on the hypothesis that a significant number of patients benefiting aorto-bi-femoral bypass
suffer isolated proximal pain/ischemia after surgery.
Amendement to the project has been recently validated to study the neurologic and bone
complication of chronic vascular ischemia
Patients included are submitted to:
San Diego Claudication Questionnaire before and during the treadmill test Treadmill test(s)
through the Strandness procedure (2MPh 10% slope) Transcutaneous oxygen pressure recording
before during and after exercise Ankle and brachial pressure measurements. Neurologic
investigation with Quantitative sensory Testing (QST) and neurophysiological tests for
patients included in the sub-group analysing neurologic complication Whole body densitometry
for patients included in the sub-group analysing osteo-articular complications
;
Observational Model: Cohort, Time Perspective: Prospective
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