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Distribution of Immune Cells and Their Subtypes in Peripheral Blood of Gout

Gout Flare Clinical Trial

Official title:
Distribution of Immune Cells and Their Subtypes in Peripheral Blood of Gout

Clinical Trial Summary

The purpose of this study is to evaluate whether immune cells and their subtypes in peripheral blood affects the asymptomatic hyperuricemia, gout flare, intercritical gout and advanced gout.

Clinical Trial Description

A number of studies have reported that innate immunity cells (such as blood monocytes and neutrophils) play a crucial role in the initiation and amplification of gout flare resulted from MSU deposition in the joint or tissue, leading to release NLRP3 inflammasome-mediated production of bioactive IL-1β. Further investigation demonstrated the role of blood neutrophils might contribute to the resolution of gout flare by forming aggregated neutrophil extracellular traps. Recently, a few in vitro experiments have indicated that adaptive immunity may be involved in mechanisms of gout. However, a global understanding of blood immune responses underlying gout is still unclear. Thus, we want to investigate the relationship between immune cells and their subtypes in peripheral blood and the gout. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05522504
Study type Observational
Source Shanghai 10th People's Hospital
Contact
Status Active, not recruiting
Phase
Start date September 15, 2022
Completion date February 2025
View Details
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