Intensive Care Clinical Trial
Official title:
Effect of EPA, GLA and Antioxidants on the Immune Response - Cellular and Molecular Mechanisms of Wound Healing in Critically Ill Patients.
The purpose of this study is to investigate whether the addition of omega-3 and antioxidants to nutritional support in critically ill patients in the intensive care unit influences the immune and anti-inflammatory systems and so improves wound healing.
A prospective randomized study to include 40 consecutive patients admitted to the general
intensive care unit. The control group will receive nutritional support composed of a
standard formula. The study group will receive nutritional support enriched with fish oil
and anti-oxidants. The following variables will be assessed in all patients: demographics,
severity of illness, assessment of bed sores. Blood tests will also be taken for the
following: CD 8, CD 14, CD 18, CD 11a, CD49c, CD 49d. In addition, blood samples will be
collected for TNF, IL-1b, IL-6, IL-8, and levels of C-reactive protein. Metabolic parameters
such as resting energy expenditure, BMI, albumin, prealbumin, levels of zinc, relationship
between omega 3 and omega 6. Theses test will be performed at time of ICU admission, days 7,
14 and 28 after admission.
The outcome: improved repair of pressure sores, together with improvement in objective
parameters of immunity and inflammation.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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