Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT04906915 |
Other study ID # |
ketamine |
Secondary ID |
|
Status |
Recruiting |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
May 8, 2021 |
Est. completion date |
May 2022 |
Study information
Verified date |
May 2021 |
Source |
First People's Hospital of Chenzhou |
Contact |
Mei XM Mei |
Phone |
86-17742594539 |
Email |
17742594539[@]163.com |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
After cardiopulmonary bypass heart surgery, with the rewarming of body temperature, the
metabolic capacity of the body is enhanced, the microcirculation is opened, and tissue
perfusion is increased. At the same time, the body pays off the oxygen debt formed by the low
temperature and reduced blood flow in cardiopulmonary bypass, so that the tissue oxygen
demand increases and oxygen consumption increases.Analgesia and sedation are important
treatment measures for patients after cardiopulmonary bypass. S-isomer of ketamine and
eselamine enhanced the sedation and enhanced the analgesic effect, but whether it can improve
the imbalance of oxygen supply and oxygen consumption after cardiopulmonary bypass is
unknown.
Description:
After cardiopulmonary bypass, the body usually appears in a state of hypermetabolism. In
addition to anesthesia resuscitation and recovery of spontaneous respiration, chills, pain
and anxiety can increase oxygen demand, increased oxygen consumption is also related to a
series of neuroendocrine reactions.At the same time, the body needs to repay the oxygen debt
formed by low temperature and reduced blood flow in extracorporeal circulation, so that the
tissue oxygen demand increases, and the systemic oxygen consumption is significantly higher
than the normal physiological state.
Sedation and analgesia treatment is one of the important early treatment measures for
patients after heart surgery. Patients with heart disease are prone to anxiety and
restlessness due to reduced cardiac function reserve, severe surgical trauma and
extracorporeal circulation, which can lead to hemodilution, tissue edema, ischemia and
reperfusion injury, etc. In addition, patients with high preoperative mental stress are prone
to anxiety and restlessness.Appropriate sedation and analgesia treatment is very important to
reduce stress response, reduce oxygen consumption and maintain the stability of hemodynamics.
The application of ketamine in sedation and analgesia has the characteristics of high
controllability, and it does not inhibit respiration and mildly excites circulation, but
whether it can improve the imbalance of oxygen supply and demand in patients after
cardiopulmonary bypass is unknown.Therefore, it is of great significance to investigate the
effect of ketamine on oxygen supply and oxygen consumption of patients after cardiopulmonary
bypass surgery.