Intensive Care Unit Clinical Trial
— LEPTOREAOfficial title:
Severe Leptospirosis in Non-tropical Areas: a Nationwide, Multicentre, Retrospective Study in French ICUs
NCT number | NCT03912506 |
Other study ID # | LEPTOREA |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | May 7, 2017 |
Est. completion date | July 9, 2018 |
Verified date | May 2019 |
Source | Nantes University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Leptospirosis is a worldwide zoonosis. The mortality of the disease is between 3,6% to 13%,
and up to 48% for the severe leptospirosis.
Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in
intensive care units in Europe. The investigators conduct a retrospective multi centric study
in metropolitan France in order to identify the characteristic, the treatments and the
prognostic factors associated with mortality of sever leptospirosis.
Status | Completed |
Enrollment | 160 |
Est. completion date | July 9, 2018 |
Est. primary completion date | July 9, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patient admitted in ICU - Leptospirosis confirmed with one laboratory test (MAT, ELISA, PCR, direct examination) Exclusion Criteria: - No specific exclusion criteria |
Country | Name | City | State |
---|---|---|---|
France | CHU Amiens-Picardie | Amiens | |
France | CHU Angers | Angers | |
France | CH Angoulème | Angoulême | |
France | CH Annecy | Annecy | |
France | CH Avignon | Avignon | |
France | hopital saint Leon, CH de la Cote Basque | Bayonne | |
France | CHU Besançon | Besançon | |
France | CH Fleyriat | Bourg-en-Bresse | |
France | CHU de Caen | Caen | |
France | CH Cahors | Cahors | |
France | CH Chartres | Chartres | |
France | CH Cholet | Cholet | |
France | CHD de la Vendée | La Roche-sur-Yon | |
France | Hopital Saint Louis | La Rochelle | |
France | CH Le Mans | Le Mans | |
France | CH Lens | Lens | |
France | CHU de Lille | Lille | |
France | Hopital Edouard Herriot, Hospices civils de Lyon | Lyon | |
France | GHR MSA | Mulhouse | |
France | CHRU de Nancy | Nancy | |
France | CH Niort | Niort | |
France | CHU Bicetre APHP | Paris | |
France | CHU Cochin APHP | Paris | |
France | CHU Henri Mondor | Paris | |
France | CHU Saint Louis, APHP | Paris | |
France | CH Périgueux | Périgueux | |
France | CH René-Dubost | Pontoise | |
France | CHU Rennes | Rennes | |
France | CHU Rouen | Rouen | |
France | CH Saint Brieuc | Saint-Brieuc | |
France | CH Saint Malo | Saint-Malo | |
France | CH Saint Nazaire | Saint-Nazaire | |
France | CHRU Bretonneau | Tours | |
France | CH Valenciennes | Valenciennes | |
France | CH Vannes | Vannes | |
France | Hopital André Mignot | Versailles |
Lead Sponsor | Collaborator |
---|---|
Nantes University Hospital |
France,
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015 Sep 17;9(9):e0003898. doi: 10.1371/journal.pntd.0003898. eCollection 2015. Review. — View Citation
Delmas B, Jabot J, Chanareille P, Ferdynus C, Allyn J, Allou N, Raffray L, Gaüzere BA, Martinet O, Vandroux D. Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions. Crit Care Med. 2018 Jan;46(1):93-99. doi: 10.1097/CCM.0000000000002825. — View Citation
Haake DA, Levett PN. Leptospirosis in humans. Curr Top Microbiol Immunol. 2015;387:65-97. doi: 10.1007/978-3-662-45059-8_5. Review. — View Citation
Picardeau M. Virulence of the zoonotic agent of leptospirosis: still terra incognita? Nat Rev Microbiol. 2017 May;15(5):297-307. doi: 10.1038/nrmicro.2017.5. Epub 2017 Mar 6. Review. — View Citation
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---|---|---|---|---|
Primary | Mortality at ICU discharge | Mortality was evaluated at ICU discharge | ICU discharge (usually 5 days) |
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