Intensive Care Unit Clinical Trial
Official title:
Severe Leptospirosis in Non-tropical Areas: a Nationwide, Multicentre, Retrospective Study in French ICUs
Leptospirosis is a worldwide zoonosis. The mortality of the disease is between 3,6% to 13%,
and up to 48% for the severe leptospirosis.
Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in
intensive care units in Europe. The investigators conduct a retrospective multi centric study
in metropolitan France in order to identify the characteristic, the treatments and the
prognostic factors associated with mortality of sever leptospirosis.
Leptospirosis is a worldwide zoonosis. The infection is acquired through contact with animal
urine on contaminated soil. It is an important remerging infectious disease because of its
increasing incidence. Leptospirosis is most common in tropical and rural settings but its
incidence has been constantly increasing for the past ten years in Metropolitan France. Most
of the cases are asymptomatic or sparsely symptomatic, but some patients develop severe
leptospirosis (6% to 59%), requiring hospitalisation in intensive care units. The mortality
of the disease is between 3,6% to 13%, and up to 48% for the severe leptospirosis.
Only few studies exist on severe leptospirosis and none major multicentre on leptospirosis in
intensive care units in Europe. Therefore, the investigators have decided to carry out this
studies. The investigators conduct a retrospective multi centric study in metropolitan France
in order to identify the characteristic, the treatments and the prognostic factors associated
with mortality of sever leptospirosis.
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