Intellectual Disability Clinical Trial
Official title:
Understanding Mental Health Crises in Youth With Intellectual and Developmental Disabilities
NCT number | NCT05471232 |
Other study ID # | 801938 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | March 29, 2023 |
Est. completion date | July 1, 2027 |
This study is an unmatched, case-control study of 150 youth (Ages 7-17) with a parent reported Intellectual Developmental Disability (IDD) who present to Rady Children's Hospital Emergency Department with a Mental Health Crisis (MHC). Rady Children's Institute for Genomic Medicine (RCIGM) will collect biological samples (such as blood) of these participants to study their genomes, medical and psychiatric profiles to better understand specific characteristics that may predispose them to MHC's. The 150 youth will be compared to historical, publicly available cohorts of youth with IDD's
Status | Recruiting |
Enrollment | 150 |
Est. completion date | July 1, 2027 |
Est. primary completion date | July 1, 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 7 Years to 17 Years |
Eligibility | Inclusion Criteria: Child/adolescents admitted to the RCHSD ED with an IDD presenting in a MHC that includes, but is not limited to: - Aggression towards others - Severe agitation - Self-injury - Elopement OR Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. (Family members are eligible for participation in this study if they presumed genetically related to a participant). Exclusion Criteria: Child/Adolescents participants who do not meet any of the inclusion criteria, or those who: - Already received any prior whole genome sequencing or exome sequencing - Unable to approach the family or patient for enrollment - Unable to obtain informed consent - family members are ineligible for participation in this study if they are known to not be genetically related to the child/adolescent participant and/or if they are a member of a protected research population. |
Country | Name | City | State |
---|---|---|---|
United States | Rady Children's Hospital San Diego | San Diego | California |
Lead Sponsor | Collaborator |
---|---|
Rady Pediatric Genomics & Systems Medicine Institute |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Diagnostic Rate | A diagnostic rate of whole genome sequencing will be compared between our primary cohort and two comparator cohorts | 4 years | |
Primary | Extract from Rady EHR demographic, biomedical, socioeconomic, and service use data for 150 youth with IDDs presenting to the ED for MHCs | Area under the receiver operating characteristic curve for a network model that predicts psychiatric outcomes for youth with intellectual and developmental disabilities. Area under the receiver operating characteristic curve has a minimum value of 0.5 and a maximum value of 1, where higher scores represent more accurate predictions of psychiatric outcomes. | 4 years | |
Secondary | Adjusted Relative Risk of Neuropsychiatric Polygenic Scores | The adjusted relative risk of neuropsychiatric polygenic scores in youth with intellectual and developmental disabilities and mental health crises compared to youth with intellectual and developmental disabilities without mental health crises. A relative risk of 1 represents equal risk between groups. A relative risk <1 represents a lower risk in the mental health crisis group and a relative risk of >1 represents a higher risk in the mental health crisis group. | 4 years |
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