Insulin Sensitivity Clinical Trial
Official title:
Comparing the Effects of Different Types of Exercise on Glucose Handling and Muscle Metabolism in Young Males and Females
NCT number | NCT06217679 |
Other study ID # | ORE #22477 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | May 1, 2018 |
Est. completion date | October 31, 2019 |
Verified date | January 2024 |
Source | University of Waterloo |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females. The exercise modalities that will be compared include: a high intensity interval exercise (HIIE) protocol, a moderate intensity continuous exercise (MICE) protocol and a low-load, high-repetition (LL-HR) resistance exercise protocol.
Status | Completed |
Enrollment | 24 |
Est. completion date | October 31, 2019 |
Est. primary completion date | October 31, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility | Inclusion Criteria: - In order to participate in this study, participants must be a healthy man or woman between the ages of 18 and 30 years. Exclusion Criteria: - Presence of chronic health condition(s) [i.e. metabolic (i.e. Type 1 or type 2 diabetes), cardiovascular (i.e hypertension), respiratory (i.e. chronic pulmonary obstructive disorder) or digestive (i.e. ulcerative colitis) disorders. - Are pregnant, or suspect that they may be pregnant, or nursing - Inability to complete the single exercise sessions. - Regularly participate in cardiovascular (>3 sessions/week) or resistance training (>2 sessions/week) exercise. - Have an allergy to local anesthetic (or family history of allergy) - Have undergone a barium swallow or an infusion of a contrast agent in the past 3 weeks - Are taking prescription anti-coagulant or anti-platelet medications (e.g., warfarin, heparin, clopidogrel) - Inability to exercise as suggested by the get active questionnaire (GAQ) - BMI > 27 kg/m2 |
Country | Name | City | State |
---|---|---|---|
Canada | University of Waterloo | Waterloo | Ontario |
Lead Sponsor | Collaborator |
---|---|
University of Waterloo |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood insulin change | To assess the effect of sex and exercise on basal and post-exercise blood insulin | 120mins | |
Primary | Blood glucose change | To assess the effect of sex and exercise on basal and post-exercise blood glucose. | 120mins | |
Primary | Blood c-peptide change | To assess the effect of sex and exercise on basal and post-exercise blood c-peptide. | 120mins | |
Primary | Insulin sensitivity change | Assess the changes in insulin sensitivity pre to post exercise | 120mins | |
Secondary | TBC1 domain family member 4 change (TBC1D4) | examine protein content changes from pre to post exercise | 35mins | |
Secondary | TBC1 domain family member 1 change (TBC1D1) | examine protein content changes from pre to post exercise | 35mins | |
Secondary | protein kinase B change | examine protein content changes from pre to post exercise | 35mins | |
Secondary | 5' adenosine monophosphate-activated protein kinase change | examine protein content changes from pre to post exercise | 35mins | |
Secondary | glucose transporter 4 change (GLUT4) | examine protein content changes from pre to post exercise | 35mins | |
Secondary | estrogen concentration | to assess the differences in estrogen concentration between males and females | 30mins | |
Secondary | progesterone concentration | to assess the differences in progesterone concentration between males and females | 30mins |
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